{"id":"W2964322184","doi":"10.1182/bloodadvances.2019000445","title":"Recurrent genetic HLA loss in AML relapsed after matched unrelated allogeneic hematopoietic cell transplantation","year":2019,"lang":"en","type":"article","venue":"Blood Advances","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute; National Institutes of Health; Howard Hughes Medical Institute","keywords":"Hematopoietic cell; Human leukocyte antigen; Hematopoietic stem cell transplantation; Transplantation; Haematopoiesis; Immunology; Oncology; Medicine; Internal medicine; Cancer research; Biology; Stem cell; Genetics; Antigen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.00008249164,0.0001849446,0.0002374126,0.0001328404,0.00004267096,0.00001091114,0.000108867,0.0001942121,0.002052713],"category_scores_gemma":[0.00000716463,0.0001701576,0.00008159319,0.0001538537,0.00004757712,0.0001860568,0.00001474006,0.0002921762,0.002256056],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002598808,"about_ca_system_score_gemma":0.00002258339,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001861654,"about_ca_topic_score_gemma":0.0000339876,"domain_scores_codex":[0.9988275,0.0001491645,0.0003785889,0.0003262384,0.00004059445,0.0002779682],"domain_scores_gemma":[0.9995548,0.00006704577,0.0001241244,0.0002026726,0.00003593363,0.00001549288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002002326,0.0008490969,0.133812,0.0003580746,0.0001170956,0.00006138621,0.001963867,0.0003517707,0.8568901,0.00005971295,0.000242792,0.003291687],"study_design_scores_gemma":[0.009616348,0.0009181808,0.1967626,0.0003970646,0.0002375547,0.00042694,0.0007185583,0.00001446518,0.7341124,0.0002432264,0.05580935,0.0007432718],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9777463,0.01717118,0.0000904306,0.00006478293,0.003070067,0.0003296596,0.000004722022,0.0000609476,0.00146192],"genre_scores_gemma":[0.9903105,0.002634819,0.00009800765,0.0001162323,0.00001381495,0.0000544301,0.0001284899,0.00001918491,0.006624449],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1227777,"threshold_uncertainty_score":0.9988595,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004261237840010862,"score_gpt":0.2100669141942042,"score_spread":0.2058056763541933,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}