{"id":"W2964322184","doi":"10.1182/bloodadvances.2019000445","title":"Recurrent genetic HLA loss in AML relapsed after matched unrelated allogeneic hematopoietic cell transplantation","year":2019,"lang":"en","type":"article","venue":"Blood Advances","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute; National Institutes of Health; Howard Hughes Medical Institute","keywords":"Hematopoietic cell; Human leukocyte antigen; Hematopoietic stem cell transplantation; Transplantation; Haematopoiesis; Immunology; Oncology; Medicine; Internal medicine; Cancer research; Biology; Stem cell; Genetics; Antigen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002037914,0.0001630823,0.0003203129,0.0007050487,0.0003377929,0.0003435388,0.0002432523,0.0003459017,0.000632179],"category_scores_gemma":[0.0008359832,0.0001344335,0.0001924634,0.0004198634,0.0003529053,0.0001310915,0.0002725041,0.0002926267,0.0001301129],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004313021,"about_ca_system_score_gemma":0.0002012794,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001003355,"about_ca_topic_score_gemma":0.001326152,"domain_scores_codex":[0.9997475,0.00003945043,0.0000284997,0.00005375014,0.00006328261,0.00006761803],"domain_scores_gemma":[0.99965,0.00005493249,0.0001520532,0.00003771781,0.00001684673,0.00008848065],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001314462,0.0001995219,0.8882303,0.00003978522,0.00007949942,0.02457487,0.0007085962,0.0005436259,0.06359191,0.0002279353,0.0002380766,0.02025145],"study_design_scores_gemma":[0.00003739116,0.0007314801,0.9315111,0.00001017285,0.00009608768,0.05585441,0.000338461,0.001136268,0.009096736,0.0002361755,0.0009372361,0.00001441992],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995803,0.0001323472,0.00007349735,0.00001746739,0.0000016684,0.00000446335,0.00002094303,0.000007210084,0.0001621068],"genre_scores_gemma":[0.9998272,0.00003013654,0.00004187405,0.00001159116,0.000003327935,0.000001513686,0.00003334551,0.000001632122,0.00004944723],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001003355,"threshold_uncertainty_score":0.003129303,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004261237840010862,"score_gpt":0.2100669141942042,"score_spread":0.2058056763541933,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}