{"id":"W2964374228","doi":"10.1126/sciadv.aax2358","title":"Vancomycin relieves mycophenolate mofetil–induced gastrointestinal toxicity by eliminating gut bacterial β-glucuronidase activity","year":2019,"lang":"en","type":"article","venue":"Science Advances","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":122,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta; Alberta Children's Hospital; University of Calgary","funders":"Canadian Donation and Transplantation Research Program","keywords":"Mycophenolate; Toxicity; Vancomycin; Medicine; Pharmacology; Microbiology; Biology; Internal medicine; Bacteria; Transplantation; Staphylococcus aureus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008913769,0.0003019057,0.0003428812,0.0002704815,0.0001141309,0.0002219465,0.0001396564,0.0003061774,0.0005219855],"category_scores_gemma":[0.0001433311,0.00009099171,0.0001944633,0.0001186869,0.0001882419,0.000102654,0.0001716581,0.0005542831,0.0001541014],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001123004,"about_ca_system_score_gemma":0.0002291569,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005046081,"about_ca_topic_score_gemma":0.001014931,"domain_scores_codex":[0.9998989,0.00002522591,0.000008622719,0.0000085836,0.00003003119,0.00002870733],"domain_scores_gemma":[0.9999193,0.000007781969,0.00003011644,0.000005269115,0.000009623425,0.00002789282],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008863898,0.0002438068,0.001050773,0.0001338883,0.00002534642,0.0003330481,0.00001617418,0.00009421731,0.9569803,0.0001372715,0.0003760871,0.03972276],"study_design_scores_gemma":[0.0005594372,0.008247849,0.03503122,0.0001068078,0.0001131601,0.003930425,0.0001106631,0.001772544,0.9305043,0.000270839,0.0193313,0.00002159013],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9859684,0.008158411,0.003145989,0.0006245414,0.0001378037,0.0000439648,0.0000872314,0.000219117,0.001614625],"genre_scores_gemma":[0.9912709,0.003582668,0.003323097,0.0002715899,0.00005897359,0.00001312168,0.0001202981,0.00002448014,0.001334865],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005219855,"threshold_uncertainty_score":0.001746237,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0070654079986823,"score_gpt":0.2717290145609196,"score_spread":0.2646636065622373,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}