{"id":"W2964457955","doi":"10.1016/j.biopsych.2019.06.031","title":"Classical Human Leukocyte Antigen Alleles and C4 Haplotypes Are Not Significantly Associated With Depression","year":2019,"lang":"en","type":"review","venue":"Biological Psychiatry","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; University of British Columbia","funders":"Cilag; National Institute of Mental Health; NHLBI Division of Intramural Research; Institute of Molecular and Cell Biology; National Health and Medical Research Council; Stanley Center for Psychiatric Research, Broad Institute; University of North Carolina at Chapel Hill; School of Medicine, Emory University; National Institutes of Health; National Institute on Alcohol Abuse and Alcoholism; Centre for Cognitive Ageing and Cognitive Epidemiology; H. Lundbeck A/S; Innovative Medicines Initiative; Chinese Society of Clinical Oncology; Medical Research Council; Siemens Healthineers; Tartu Ülikool; Leids Universitair Medisch Centrum; Westfälische Wilhelms-Universität Münster; Dokuz Eylül Üniversitesi; Vetenskapsrådet; Medizinische Fakultät der Albert-Ludwigs-Universität Freiburg; GGZ Drenthe; Pfizer; Rivierduinen; GGZ inGeest; Gentofte Hospital; Deutsche Forschungsgemeinschaft; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Háskóli Íslands; Bundesministerium für Bildung und Forschung; Erasmus Medisch Centrum; Vrije Universiteit Amsterdam; Janssen Research and Development; ZonMw; Rijksuniversiteit Groningen; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Universiteit Leiden; University of Toronto; Institute of Genetics; Department of Psychiatry, University of Toronto; Universität Greifswald; GGZ Friesland; National Cancer Institute; University College London; Lundbeckfonden; Albert-Ludwigs-Universität Freiburg; Max-Planck-Gesellschaft; King's College London; Department of Health and Social Care; Rheinische Friedrich-Wilhelms-Universität Bonn; Universitair Medisch Centrum Groningen; Università degli Studi di Trento; Virginia Commonwealth University; Philipps-Universität Marburg; Aarhus Universitet; Universität Basel; QIMR Berghofer Medical Research Institute; Højteknologifonden; Johns Hopkins University; National Institute for Health and Care Research; Aarhus Universitetshospital; University of Southern California; Foundation for the National Institutes of Health; Broad Institute; F. Hoffmann-La Roche; Dalhousie University; GlaxoSmithKline; Universitätsmedizin Göttingen; Queensland Brain Institute; Karolinska Institutet; University of Queensland; Emory University; Cardiff University; Kaiser Permanente; Wellcome Trust; National Science Foundation; Massachusetts General Hospital; AstraZeneca; University of Worcester","keywords":"Human leukocyte antigen; Haplotype; Major histocompatibility complex; Allele; Odds ratio; Depression (economics); Genetics; Immunology; Biology; Medicine; Internal medicine; Gene; Antigen","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001050032,0.000595891,0.002400899,0.001135057,0.0001582327,0.0007636884,0.001004053,0.0009613223,0.002637676],"category_scores_gemma":[0.002447874,0.0002178724,0.001288931,0.001603627,0.0003511149,0.0003972394,0.000348167,0.0006928114,0.0003728498],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005118979,"about_ca_system_score_gemma":0.001322382,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002553187,"about_ca_topic_score_gemma":0.003887044,"domain_scores_codex":[0.9995937,0.0001257236,0.0000895847,0.00008779971,0.00007364539,0.00002953012],"domain_scores_gemma":[0.9985703,0.001001441,0.0002249029,0.00002592128,0.0001346599,0.0000427904],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"systematic_review","study_design_scores_codex":[0.001137609,0.0000448254,0.008321187,0.09062969,0.007413931,0.0003379497,0.00006062054,0.000349173,0.000764371,0.001496629,0.0115121,0.8779318],"study_design_scores_gemma":[0.001091021,0.001618001,0.1513583,0.1469288,0.06073966,0.01227484,0.000402152,0.001007415,0.002059487,0.009298477,0.6130378,0.0001840035],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003588297,0.9992324,0.00002934957,0.000135183,0.00003909401,0.000001706472,0.00001977024,0.000001186019,0.0001824785],"genre_scores_gemma":[0.006878074,0.9924279,0.0001271393,0.0001917782,0.000123452,0.000007536104,0.00007058552,0.000001424849,0.0001720992],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002637676,"threshold_uncertainty_score":0.008823931,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.152375883146754,"score_gpt":0.3372602284636235,"score_spread":0.1848843453168695,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}