{"id":"W2964457955","doi":"10.1016/j.biopsych.2019.06.031","title":"Classical Human Leukocyte Antigen Alleles and C4 Haplotypes Are Not Significantly Associated With Depression","year":2019,"lang":"en","type":"review","venue":"Biological Psychiatry","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; University of British Columbia","funders":"Cilag; National Institute of Mental Health; NHLBI Division of Intramural Research; Institute of Molecular and Cell Biology; National Health and Medical Research Council; Stanley Center for Psychiatric Research, Broad Institute; University of North Carolina at Chapel Hill; School of Medicine, Emory University; National Institutes of Health; National Institute on Alcohol Abuse and Alcoholism; Centre for Cognitive Ageing and Cognitive Epidemiology; H. Lundbeck A/S; Innovative Medicines Initiative; Chinese Society of Clinical Oncology; Medical Research Council; Siemens Healthineers; Tartu Ülikool; Leids Universitair Medisch Centrum; Westfälische Wilhelms-Universität Münster; Dokuz Eylül Üniversitesi; Vetenskapsrådet; Medizinische Fakultät der Albert-Ludwigs-Universität Freiburg; GGZ Drenthe; Pfizer; Rivierduinen; GGZ inGeest; Gentofte Hospital; Deutsche Forschungsgemeinschaft; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Háskóli Íslands; Bundesministerium für Bildung und Forschung; Erasmus Medisch Centrum; Vrije Universiteit Amsterdam; Janssen Research and Development; ZonMw; Rijksuniversiteit Groningen; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Universiteit Leiden; University of Toronto; Institute of Genetics; Department of Psychiatry, University of Toronto; Universität Greifswald; GGZ Friesland; National Cancer Institute; University College London; Lundbeckfonden; Albert-Ludwigs-Universität Freiburg; Max-Planck-Gesellschaft; King's College London; Department of Health and Social Care; Rheinische Friedrich-Wilhelms-Universität Bonn; Universitair Medisch Centrum Groningen; Università degli Studi di Trento; Virginia Commonwealth University; Philipps-Universität Marburg; Aarhus Universitet; Universität Basel; QIMR Berghofer Medical Research Institute; Højteknologifonden; Johns Hopkins University; National Institute for Health and Care Research; Aarhus Universitetshospital; University of Southern California; Foundation for the National Institutes of Health; Broad Institute; F. Hoffmann-La Roche; Dalhousie University; GlaxoSmithKline; Universitätsmedizin Göttingen; Queensland Brain Institute; Karolinska Institutet; University of Queensland; Emory University; Cardiff University; Kaiser Permanente; Wellcome Trust; National Science Foundation; Massachusetts General Hospital; AstraZeneca; University of Worcester","keywords":"Human leukocyte antigen; Haplotype; Major histocompatibility complex; Allele; Odds ratio; Depression (economics); Genetics; Immunology; Biology; Medicine; Internal medicine; Gene; Antigen","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000178365,0.0006638786,0.001590396,0.0001217665,0.0003061786,0.0001037325,0.0006227666,0.0009320075,0.00006923721],"category_scores_gemma":[0.0003669306,0.0003690464,0.000347992,0.0003146165,0.0005008525,0.00007004565,0.0002066074,0.0007679397,0.0001276431],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004019653,"about_ca_system_score_gemma":0.0001383457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003380972,"about_ca_topic_score_gemma":0.00002974469,"domain_scores_codex":[0.9965531,0.000628063,0.0005354158,0.001404053,0.0003143917,0.0005650067],"domain_scores_gemma":[0.9981797,0.0005487893,0.0006167445,0.0004410057,0.00002372242,0.0001900548],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001252646,0.007608536,0.07698692,0.01926034,0.001175717,0.000388721,0.0001430501,0.00000489788,0.008044095,0.02243843,0.0377897,0.8249069],"study_design_scores_gemma":[0.001617315,0.001244745,0.0454983,0.009732201,0.0002703693,0.0000539452,0.00006195505,0.000007303442,0.0001207316,0.0007103096,0.9386331,0.002049761],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02843923,0.9682271,0.00001073442,0.0001813224,0.0005153113,0.001099099,0.0001433353,0.0003409237,0.001042925],"genre_scores_gemma":[0.03401906,0.9643618,0.00008641156,0.0007018827,0.0002302237,0.00005191498,0.00009049974,0.00007261423,0.0003856304],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9008434,"threshold_uncertainty_score":0.9998761,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.152375883146754,"score_gpt":0.3372602284636235,"score_spread":0.1848843453168695,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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