{"id":"W2964488893","doi":"10.1182/blood.2019001279","title":"Lysine acetyltransferase Tip60 is required for hematopoietic stem cell maintenance","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute; Medical Research Council; Cancer Research UK; Wellcome Trust","keywords":"Biology; Histone acetyltransferase; Chromatin; Stem cell; Haematopoiesis; Cell biology; Epigenetics; Acetyltransferase; Progenitor cell; Acetylation; Molecular biology; Cancer research; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008214774,0.0002358089,0.0002560255,0.0002475893,0.0001943678,0.0003472212,0.0002080975,0.0002896479,0.001472697],"category_scores_gemma":[0.0001886422,0.0001460343,0.0001810058,0.0001733467,0.0002082994,0.0001728624,0.0003849515,0.0003478271,0.001017076],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002063733,"about_ca_system_score_gemma":0.0001432798,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004338181,"about_ca_topic_score_gemma":0.0005143498,"domain_scores_codex":[0.9998504,0.00000997853,0.00001588136,0.00004404939,0.00005242106,0.00002721084],"domain_scores_gemma":[0.9998192,0.0000146097,0.00005958764,0.00001779156,0.00001791041,0.00007091902],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002922159,0.000003269542,0.0004902368,0.00001565791,0.000002536721,0.00006739422,0.000004445237,0.00002250019,0.998,0.00004998069,0.00005249818,0.001262331],"study_design_scores_gemma":[0.00001431096,0.0001024677,0.05811243,0.00001256794,0.00002477519,0.001005914,0.00004081976,0.001211938,0.933121,0.0002609428,0.006082789,0.00001002758],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9831443,0.004045859,0.007819974,0.000180649,0.00006557839,0.00002068384,0.001733545,0.0004599134,0.002529359],"genre_scores_gemma":[0.9956723,0.000636406,0.001219028,0.00005159325,0.00001104021,0.000008550872,0.001013715,0.00003192177,0.001355482],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001472697,"threshold_uncertainty_score":0.004926682,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01764870625888844,"score_gpt":0.2356534879508992,"score_spread":0.2180047816920108,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}