{"id":"W2964512516","doi":"10.3389/fnins.2019.00861","title":"Pre-plaque Aß-Mediated Impairment of Synaptic Depotentiation in a Transgenic Rat Model of Alzheimer’s Disease Amyloidosis","year":2019,"lang":"en","type":"article","venue":"Frontiers in Neuroscience","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Frontiers Foundation; Science Foundation Ireland; National Natural Science Foundation of China; McGill University","keywords":"Long-term potentiation; Neuroscience; Synaptic plasticity; NMDA receptor; Synapse; Genetically modified mouse; Synapsin I; Chemistry; Transgene; Stimulation; Amyloid (mycology); Psychology; Receptor; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005450146,0.0002538105,0.000460434,0.0009601048,0.00007582599,0.00002802623,0.001108315,0.00007915524,0.00001409384],"category_scores_gemma":[0.0005591215,0.0002470593,0.0001298439,0.002390445,0.000799367,0.000694731,0.000182702,0.000420949,0.000007059075],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006453146,"about_ca_system_score_gemma":0.0003951351,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001662292,"about_ca_topic_score_gemma":0.000003962232,"domain_scores_codex":[0.9959415,0.0004720425,0.0007420835,0.001123495,0.0009615891,0.0007593213],"domain_scores_gemma":[0.9987456,0.0001825455,0.0002695578,0.0005197244,0.00004454353,0.0002380073],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003510327,0.0004883416,0.06963698,0.0000602206,0.000001082886,0.00004077889,0.0001868586,0.02760967,0.9014032,0.00004094471,0.00006303439,0.0001178706],"study_design_scores_gemma":[0.001010598,0.0003093462,0.02823421,0.00003903519,0.00001531084,0.000003788744,0.0000188377,0.4138564,0.5561855,0.0001433137,0.000009061548,0.0001746134],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959313,0.00009583928,0.0009690809,0.0002869869,0.001319302,0.00127515,0.00004706156,0.00003227164,0.00004298843],"genre_scores_gemma":[0.9984598,0.0006152156,0.0001215468,0.0006132605,0.000006119565,0.00007456786,8.002364e-7,0.00002485345,0.00008390909],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3862467,"threshold_uncertainty_score":0.9999982,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03323526946329986,"score_gpt":0.2952087338438111,"score_spread":0.2619734643805112,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}