{"id":"W2964569023","doi":"10.1126/sciadv.aau9433","title":"Efficient apoptosis requires feedback amplification of upstream apoptotic signals by effector caspase-3 or -7","year":2019,"lang":"en","type":"article","venue":"Science Advances","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":271,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute for Empirical Research in Economics, University of Zurich; National Research Council Canada; Canadian Institutes of Health Research; Universität Zürich; Novartis Foundation; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Effector; Upstream (networking); Apoptosis; Cell biology; Caspase; Caspase 8; Caspase 3; Computer science; Biology; Telecommunications; Genetics; Programmed cell death","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002266288,0.0002770395,0.0002749017,0.0001566525,0.0001206419,0.0004288639,0.000241081,0.0003034012,0.0008081883],"category_scores_gemma":[0.0002112953,0.0001369584,0.0003017966,0.0001142939,0.0003043004,0.0003187517,0.0003065957,0.0008816007,0.0004062885],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002882333,"about_ca_system_score_gemma":0.0003076521,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002073652,"about_ca_topic_score_gemma":0.0003760678,"domain_scores_codex":[0.9996886,0.00004602758,0.00002481894,0.00004928912,0.0001167509,0.00007446623],"domain_scores_gemma":[0.9998645,0.00003190143,0.00003756187,0.00002018848,0.00001990367,0.00002597335],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006386752,0.00001715139,0.0001676748,0.00002139837,0.000003817115,0.00004019608,0.000007458225,0.00009196343,0.9979112,0.000305104,0.00002550799,0.001344603],"study_design_scores_gemma":[0.00001398429,0.00007749217,0.001155991,0.000004044485,0.000005843046,0.0001650469,0.000008815224,0.0008642959,0.9964893,0.0001882868,0.001023653,0.000003078305],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9809865,0.001402807,0.01491307,0.0001871489,0.00003717195,0.00003384622,0.0002406592,0.0001921742,0.002006503],"genre_scores_gemma":[0.9941834,0.0005037134,0.004130345,0.00004695181,0.000005363781,0.00002169023,0.000187731,0.00001617635,0.0009046406],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008081883,"threshold_uncertainty_score":0.002703607,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007593838994077451,"score_gpt":0.2628216891535907,"score_spread":0.2552278501595132,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}