{"id":"W2964577788","doi":"10.3390/cancers11081066","title":"Diminished Condensin Gene Expression Drives Chromosome Instability That May Contribute to Colorectal Cancer Pathogenesis","year":2019,"lang":"en","type":"article","venue":"Cancers","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Research Institute in Oncology and Hematology; CancerCare Manitoba","funders":"University of Bristol; Strong; Natural Sciences and Engineering Research Council of Canada; CancerCare Manitoba Foundation","keywords":"Chromosome instability; Condensin; Biology; Genome instability; Gene silencing; Genetics; Cancer; Phenotype; Gene; Chromosome; Cancer research; Mitosis; Colorectal cancer; Chromosome segregation; DNA damage; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001101904,0.0002107371,0.0002529332,0.00002852212,0.00007563582,0.0000310973,0.0002308721,0.0001727866,0.000140104],"category_scores_gemma":[0.00002776907,0.0002021131,0.0001029777,0.00007856772,0.00006879138,0.00000508571,0.0001777888,0.00006920587,0.0000222436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003648087,"about_ca_system_score_gemma":0.0004502089,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001034666,"about_ca_topic_score_gemma":0.0002406156,"domain_scores_codex":[0.9987363,0.00004829598,0.0001926262,0.0005358119,0.0001437046,0.0003432553],"domain_scores_gemma":[0.9992113,0.00001368042,0.0001035722,0.0004021301,0.00009911505,0.0001702173],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001381442,0.00001071011,0.04308637,0.00002302383,0.0000387213,0.000002282305,0.0001060181,0.002585229,0.9528411,0.000006764527,0.0005285881,0.0006330376],"study_design_scores_gemma":[0.0007752427,0.0002565637,0.03392214,0.00002913681,0.0000187505,0.000004643953,0.0001590686,0.0003133336,0.9558915,0.0000140318,0.008282861,0.0003327337],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972148,0.0006187481,0.0001415895,0.0001104683,0.0006884951,0.0005027709,0.0004346379,0.00001749711,0.0002710055],"genre_scores_gemma":[0.9978406,0.0002397197,0.0006533712,0.0004323077,0.0001445512,0.0001006412,0.0001846497,0.00003452904,0.0003696085],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009164234,"threshold_uncertainty_score":0.8241932,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007490807365020723,"score_gpt":0.2357148416753808,"score_spread":0.22822403431036,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}