{"id":"W2964578788","doi":"10.1016/j.ajhg.2019.06.012","title":"Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways","year":2019,"lang":"en","type":"review","venue":"The American Journal of Human Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":131,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"National Institute of Mental Health; Biotechnology and Biological Sciences Research Council; Medical Research Council","keywords":"Schizophrenia (object-oriented programming); Cognition; Genome-wide association study; Genetic association; Meta-analysis; Psychology; Biology; Genetics; Neuroscience; Medicine; Psychiatry; Single-nucleotide polymorphism; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002795212,0.0002535653,0.002244283,0.0002458336,0.00006431006,0.00001465349,0.0002955141,0.00008978076,0.00001095729],"category_scores_gemma":[0.00007936332,0.0001638233,0.0007174171,0.0002237543,0.0004067416,0.000002284527,0.0001314857,0.0001564386,4.097103e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008269841,"about_ca_system_score_gemma":0.0002378773,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001211366,"about_ca_topic_score_gemma":0.00001840444,"domain_scores_codex":[0.9979978,0.0004632773,0.001024771,0.0002186641,0.0001504314,0.0001451138],"domain_scores_gemma":[0.9963681,0.0001114833,0.002744468,0.0003046602,0.0004065181,0.00006480915],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.0001413132,0.0006442458,0.02430013,0.002762146,0.4585463,0.000002248853,0.001170892,0.0001027095,0.004621002,0.0002601676,0.0004571663,0.5069917],"study_design_scores_gemma":[0.0007793342,0.005193398,0.1944579,0.0004680697,0.7906123,0.0002045854,0.001159156,0.00002536032,0.0002909457,0.0007671167,0.005085389,0.0009564196],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.4901381,0.5096436,0.0000333056,0.00001163723,0.00002158237,0.00009310002,0.00005274391,5.453321e-7,0.000005324933],"genre_scores_gemma":[0.3979983,0.6011811,0.000651226,0.00003251656,0.00003940341,0.000005293394,0.00005920968,0.00001618342,0.00001677897],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.5060353,"threshold_uncertainty_score":0.6680519,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04502148145555727,"score_gpt":0.3131777669527975,"score_spread":0.2681562854972402,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}