{"id":"W2964589739","doi":"10.3390/cancers11081129","title":"High Level Expression of MHC-II in HPV+ Head and Neck Cancers Suggests that Tumor Epithelial Cells Serve an Important Role as Accessory Antigen Presenting Cells","year":2019,"lang":"en","type":"article","venue":"Cancers","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"Canadian Institutes of Health Research","keywords":"CIITA; Antigen presentation; Major histocompatibility complex; Downregulation and upregulation; Antigen processing; Antigen; Cancer research; MHC class I; Antigen-presenting cell; Biology; T cell; Immunology; MHC class II; Immune system; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003327987,0.0002974416,0.0005521054,0.0001792768,0.0001741253,0.00002417015,0.0003962902,0.0002429645,0.0007429358],"category_scores_gemma":[0.00001851727,0.0002686503,0.00009505952,0.0001587261,0.0002234728,0.0003907625,0.0001668263,0.0003379759,0.00003207457],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003250133,"about_ca_system_score_gemma":0.0007332608,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01746769,"about_ca_topic_score_gemma":0.0006598097,"domain_scores_codex":[0.9980794,0.000281726,0.0004983385,0.0004903511,0.00008204421,0.0005681597],"domain_scores_gemma":[0.998918,0.0001147262,0.0003986388,0.0004673526,0.00006185549,0.00003945326],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001629524,0.00004292235,0.03183979,0.00005953929,0.00007131959,0.000006913288,0.002555775,0.0003735232,0.9623713,0.00001870157,0.0001540829,0.0008766465],"study_design_scores_gemma":[0.002614722,0.0004091011,0.08052558,0.000186924,0.00001419283,0.00001269743,0.001137558,0.00001749319,0.9098036,0.00004024235,0.004943416,0.0002944721],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904628,0.007272339,0.00000148018,0.00002911785,0.001292123,0.0005129156,0.000203727,0.00003282818,0.0001926776],"genre_scores_gemma":[0.9958595,0.001617303,0.00005095005,0.0001392226,0.00003444933,0.00002908152,0.00004861801,0.00004130303,0.00217956],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05256766,"threshold_uncertainty_score":0.9999766,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01743020920485805,"score_gpt":0.2623250687343114,"score_spread":0.2448948595294533,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}