{"id":"W2964655403","doi":"10.3390/cancers11101428","title":"STAT3 and STAT5 Activation in Solid Cancers","year":2019,"lang":"en","type":"review","venue":"Cancers","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":106,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"Cancer research; Biology; STAT3; Suppressor of cytokine signaling 1; SOCS6; SOCS3; STAT protein; Ubiquitin ligase; Tumor suppressor gene; Signal transduction; Cell biology; Transcription factor; Cancer; Carcinogenesis; Ubiquitin; Suppressor; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008068896,0.0002279345,0.0009795894,0.0002551361,0.00002782229,0.00001895,0.00005062525,0.0001403412,0.0002287286],"category_scores_gemma":[0.00004946109,0.0001923119,0.0001385231,0.0002379585,0.00003936546,0.00008179482,0.00002054073,0.0004500228,0.00002712076],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004728466,"about_ca_system_score_gemma":0.003498011,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001711534,"about_ca_topic_score_gemma":0.0001748526,"domain_scores_codex":[0.9989519,0.00003046081,0.0003453981,0.0003239121,0.0001321825,0.0002162065],"domain_scores_gemma":[0.9993575,0.00008613893,0.0001985744,0.000219565,0.00004722615,0.00009096207],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003671703,0.000007365111,0.00001242717,0.01183997,0.0001489656,0.000009228865,0.0002201062,0.00007899987,0.00006717384,0.00004191187,0.005417478,0.9821197],"study_design_scores_gemma":[0.0003751742,0.0001211631,0.00001020685,0.02008996,0.0002791187,0.0000153972,0.00009900362,0.00007047346,0.00003862386,0.00000490119,0.9787179,0.000178125],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002874387,0.9953796,0.00003619009,0.00003919138,0.0005408639,0.0007984202,0.00007853012,0.00002638542,0.002813424],"genre_scores_gemma":[0.0004747422,0.9978606,0.00004107771,0.0001606664,0.0002115792,0.0001060737,0.0001627769,0.00004516829,0.0009373365],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9819415,"threshold_uncertainty_score":0.9990922,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09724841275879982,"score_gpt":0.4060361511140844,"score_spread":0.3087877383552846,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}