{"id":"W2964663086","doi":"10.3389/fonc.2019.00772","title":"IDH1 as a Cooperating Mutation in AML Arising in the Context of Shwachman-Diamond Syndrome","year":2019,"lang":"en","type":"article","venue":"Frontiers in Oncology","topic":"Blood disorders and treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont; Université de Montréal; Institute for Research in Immunology and Cancer; McGill University; Centre Hospitalier Universitaire Sainte-Justine; Montreal Children's Hospital","funders":"Fondation Charles-Bruneau; Canadian Cancer Society Research Institute; Rare Disease Foundation","keywords":"Bone marrow; Myeloid leukemia; Pathology; Context (archaeology); Leukemia; Myeloid; Medicine; Neutropenia; Myelodysplastic syndromes; Bone marrow failure; Cancer research; Haematopoiesis; Biology; Internal medicine; Stem cell; Genetics; Chemotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001084769,0.0004123857,0.0002554094,0.0008255022,0.0004127873,0.0003163078,0.0003178574,0.0008609774,0.001001782],"category_scores_gemma":[0.0006020052,0.0001653592,0.0001862107,0.0003253859,0.0004965717,0.0002683403,0.0004623867,0.0004024196,0.0002031233],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003467636,"about_ca_system_score_gemma":0.0001927324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009447447,"about_ca_topic_score_gemma":0.001252151,"domain_scores_codex":[0.9998593,0.00001324244,0.00001357332,0.00004875318,0.00002873304,0.00003633045],"domain_scores_gemma":[0.9997645,0.00007183801,0.00005617746,0.00001214261,0.0000128341,0.00008248917],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.0001783573,0.00003322276,0.06517113,0.00006329476,0.0000161556,0.8989689,0.0003539694,0.0002919815,0.02728806,0.0006593724,0.0003848132,0.006590703],"study_design_scores_gemma":[0.0000224052,0.0001235719,0.04773078,0.00002116753,0.00004513019,0.9380777,0.0001910155,0.001060809,0.009476271,0.0006559078,0.002574524,0.00002072901],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965492,0.0008768081,0.0005963917,0.0001922737,0.00002264307,0.00002255177,0.0001023612,0.00004552785,0.001592173],"genre_scores_gemma":[0.9992325,0.0001432927,0.0003294121,0.00004058743,0.00002041927,0.000002355904,0.00003795676,0.000003733621,0.0001897342],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001001782,"threshold_uncertainty_score":0.003351271,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005555785418982856,"score_gpt":0.260264649455685,"score_spread":0.2547088640367021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}