{"id":"W2964663086","doi":"10.3389/fonc.2019.00772","title":"IDH1 as a Cooperating Mutation in AML Arising in the Context of Shwachman-Diamond Syndrome","year":2019,"lang":"en","type":"article","venue":"Frontiers in Oncology","topic":"Blood disorders and treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont; Université de Montréal; Institute for Research in Immunology and Cancer; McGill University; Centre Hospitalier Universitaire Sainte-Justine; Montreal Children's Hospital","funders":"Fondation Charles-Bruneau; Canadian Cancer Society Research Institute; Rare Disease Foundation","keywords":"Bone marrow; Myeloid leukemia; Pathology; Context (archaeology); Leukemia; Myeloid; Medicine; Neutropenia; Myelodysplastic syndromes; Bone marrow failure; Cancer research; Haematopoiesis; Biology; Internal medicine; Stem cell; Genetics; Chemotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000251149,0.00009700625,0.0002386406,0.000103163,0.00001628297,0.000006951231,0.0001365866,0.0001808976,0.000009530746],"category_scores_gemma":[0.00006056946,0.00008202591,0.00003431565,0.0001550357,0.00005615563,0.000005927023,0.00003512055,0.0001214443,0.000005165482],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004950113,"about_ca_system_score_gemma":0.0001041905,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004432085,"about_ca_topic_score_gemma":0.001523013,"domain_scores_codex":[0.9991068,0.0001667066,0.0002564589,0.0002205619,0.00006407204,0.0001854296],"domain_scores_gemma":[0.9996886,0.00002798517,0.00008556651,0.0001635906,0.00001885294,0.00001537383],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003030864,0.0008377502,0.9411786,0.00003670216,0.00007832666,0.0002462731,0.00341947,0.0004990085,0.01241269,0.0002178201,0.001277891,0.0394924],"study_design_scores_gemma":[0.06624202,0.0205992,0.6361737,0.0005465815,0.0002082292,0.001023962,0.1409724,0.006930325,0.08118166,0.007873853,0.03608449,0.002163607],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950296,0.001528747,0.00008852685,0.0001942033,0.000253976,0.0003659499,0.000004188141,0.0000017548,0.002533095],"genre_scores_gemma":[0.9984462,0.0000819066,0.0008562267,0.0004276104,0.00001070573,0.0000369287,0.00005967291,0.00000901638,0.00007171305],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3050049,"threshold_uncertainty_score":0.3344919,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005555785418982856,"score_gpt":0.260264649455685,"score_spread":0.2547088640367021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}