{"id":"W2964673115","doi":"10.1158/1078-0432.ccr-19-1423","title":"The Role of Lineage Plasticity in Prostate Cancer Therapy Resistance","year":2019,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":394,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Cancer Institute","keywords":"Prostate cancer; Lineage (genetic); Cancer; Resistance (ecology); Medicine; Cancer therapy; Biology; Internal medicine; Genetics; Ecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002410122,0.0002610676,0.0007445577,0.0005869099,0.0006284269,0.002739363,0.0007311598,0.0009371463,0.002586522],"category_scores_gemma":[0.002694056,0.0001836416,0.0003358011,0.0005862541,0.001862248,0.001697582,0.001597706,0.003739545,0.0006654902],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001846892,"about_ca_system_score_gemma":0.002454102,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009648674,"about_ca_topic_score_gemma":0.001269178,"domain_scores_codex":[0.9987889,0.0005969972,0.0000621218,0.000121643,0.0002881174,0.0001422354],"domain_scores_gemma":[0.9981982,0.0008294287,0.0003278048,0.0001236234,0.0002941821,0.0002267809],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0006107201,0.0001942579,0.01176284,0.002766898,0.000134296,0.001022053,0.001127334,0.003187311,0.03586985,0.119262,0.03778077,0.7862816],"study_design_scores_gemma":[0.0001121226,0.001480365,0.01755087,0.001745309,0.0001990812,0.006362994,0.00103916,0.003754321,0.02026515,0.07980686,0.8675769,0.0001069169],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.04448948,0.8535718,0.0157997,0.05770897,0.00152269,0.0001629924,0.0003678398,0.0003149475,0.02606151],"genre_scores_gemma":[0.5050725,0.4665959,0.006646812,0.01263693,0.0024796,0.000231807,0.0004036498,0.00009484749,0.005838044],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.002739363,"threshold_uncertainty_score":0.0134002,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1459517182911886,"score_gpt":0.5267830732056228,"score_spread":0.3808313549144342,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}