{"id":"W2964676038","doi":"10.1016/j.bbagrm.2019.194409","title":"Plasticity at the DNA recognition site of the MeCP2 mCG-binding domain","year":2019,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Structural Genomics Consortium","funders":"Eshelman Institute for Innovation, University of North Carolina at Chapel Hill; Janssen Pharmaceuticals; Pfizer; Natural Sciences and Engineering Research Council of Canada; National Research Council Canada; Canadian Institutes of Health Research; Beijing Novartis Pharma; Innovative Medicines Initiative; National Institutes of Health; Canada Foundation for Innovation; Ontario Ministry of Research, Innovation and Science; Argonne National Laboratory; National Institute of General Medical Sciences; Ontario Genomics Institute; Western Economic Diversification Canada; Wellcome Trust; Genome Canada; University of Saskatchewan; National Cancer Institute; Takeda Pharmaceutical Company; Novartis Pharma; Merck KGaA; Howard Hughes Medical Institute; U.S. Department of Energy; Janssen Biotech; Meso Scale Diagnostics; Office of Science; Boehringer Ingelheim","keywords":"MECP2; DNA; Computational biology; DNA binding site; Computer science; Genetics; Biology; Neuroscience; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002092571,0.0002484851,0.0002939331,0.0001998335,0.0002777075,0.000351414,0.0005167885,0.0004004574,0.00524959],"category_scores_gemma":[0.0005857224,0.0001755501,0.0002593367,0.0001122079,0.0003848321,0.0003047417,0.000407072,0.0005523994,0.001387278],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003308573,"about_ca_system_score_gemma":0.0002454172,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001048752,"about_ca_topic_score_gemma":0.00120521,"domain_scores_codex":[0.9998203,0.00002813626,0.00001002663,0.00004927568,0.00004643764,0.00004584609],"domain_scores_gemma":[0.9996793,0.00009276264,0.00004404021,0.00004689742,0.00004770332,0.00008931988],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002451533,0.0000122374,0.0007642237,0.00003295278,0.00001030764,0.0001787252,0.00002280973,0.000343468,0.994661,0.0005901697,0.00009235801,0.003046509],"study_design_scores_gemma":[0.00008354543,0.0003810206,0.03568263,0.0000360919,0.00006803268,0.002109707,0.0001368476,0.00984999,0.944845,0.001790619,0.004952732,0.0000636603],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9842539,0.0008646965,0.01018109,0.0001584084,0.00008995331,0.00002623001,0.0002003606,0.0001768033,0.004048527],"genre_scores_gemma":[0.9980824,0.00007333124,0.0009254965,0.00006594109,0.00001037435,0.000008968838,0.00008139943,0.00001998214,0.0007321434],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00524959,"threshold_uncertainty_score":0.01756161,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008425870186976683,"score_gpt":0.2014467953306704,"score_spread":0.1930209251436937,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}