{"id":"W2964676038","doi":"10.1016/j.bbagrm.2019.194409","title":"Plasticity at the DNA recognition site of the MeCP2 mCG-binding domain","year":2019,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Structural Genomics Consortium","funders":"Eshelman Institute for Innovation, University of North Carolina at Chapel Hill; Janssen Pharmaceuticals; Pfizer; Natural Sciences and Engineering Research Council of Canada; National Research Council Canada; Canadian Institutes of Health Research; Beijing Novartis Pharma; Innovative Medicines Initiative; National Institutes of Health; Canada Foundation for Innovation; Ontario Ministry of Research, Innovation and Science; Argonne National Laboratory; National Institute of General Medical Sciences; Ontario Genomics Institute; Western Economic Diversification Canada; Wellcome Trust; Genome Canada; University of Saskatchewan; National Cancer Institute; Takeda Pharmaceutical Company; Novartis Pharma; Merck KGaA; Howard Hughes Medical Institute; U.S. Department of Energy; Janssen Biotech; Meso Scale Diagnostics; Office of Science; Boehringer Ingelheim","keywords":"MECP2; DNA; Computational biology; DNA binding site; Computer science; Genetics; Biology; Neuroscience; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002398404,0.0003513995,0.0002593091,0.00005106793,0.000258282,0.00003041181,0.0004944286,0.0002102612,0.00006149151],"category_scores_gemma":[0.00002315253,0.0002474213,0.0002966736,0.0002186863,0.0001743906,0.000008381336,0.0006379673,0.0001481067,0.00008626278],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000411566,"about_ca_system_score_gemma":0.0001026677,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005957355,"about_ca_topic_score_gemma":0.0000206717,"domain_scores_codex":[0.9979827,0.0001999731,0.0003718448,0.0006471199,0.0004103515,0.0003879434],"domain_scores_gemma":[0.9987127,0.00003057098,0.0003375995,0.0007528883,0.00007698499,0.00008923776],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001095131,0.00008221656,0.000004716084,0.00002360628,0.0000847394,3.584529e-7,0.000110253,0.00001529562,0.998811,0.0001438298,0.0004037354,0.0002107415],"study_design_scores_gemma":[0.0005583988,0.0002224915,0.01035594,0.00003485573,0.00005356611,0.00001137177,0.00009156318,0.00002895561,0.9870595,0.0009979582,0.0002483841,0.0003370292],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977906,0.0000487935,0.0001324169,0.0003974483,0.0004575299,0.0006250694,0.0002179649,0.00001840087,0.0003117553],"genre_scores_gemma":[0.9978245,0.00009758079,0.0005440884,0.0005018695,0.00004864679,0.00003179963,0.0002275465,0.00006361985,0.0006602752],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01175151,"threshold_uncertainty_score":0.9999978,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008425870186976683,"score_gpt":0.2014467953306704,"score_spread":0.1930209251436937,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}