{"id":"W2964681165","doi":"10.1182/bloodadvances.2019000306","title":"Impact of preleukemic mutations and their persistence on hematologic recovery after induction chemotherapy for AML","year":2019,"lang":"en","type":"article","venue":"Blood Advances","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network; Princess Margaret Cancer Centre","funders":"","keywords":"Persistence (discontinuity); Mutation; Chemotherapy; Allele; Induction chemotherapy; Medicine; Leukemia; Immunology; Oncology; Biology; Genetics; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008879584,0.0001158796,0.000249504,0.0001004739,0.00002812748,0.000007444509,0.00005446041,0.00006684952,0.00005969258],"category_scores_gemma":[0.00008750563,0.00007541498,0.0001140774,0.000124187,0.00008224734,0.0001621069,0.00001222779,0.0001149297,0.000007019146],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001011417,"about_ca_system_score_gemma":0.0001448022,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009225243,"about_ca_topic_score_gemma":0.00000208877,"domain_scores_codex":[0.9993372,0.00001821091,0.0001441045,0.0002271813,0.0001003921,0.0001729345],"domain_scores_gemma":[0.9994205,0.0001656332,0.00008095621,0.0001900428,0.00009027147,0.00005259726],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0172571,0.001665008,0.3971263,0.002470489,0.001617683,0.00002079168,0.00391968,0.0008520914,0.4587044,0.0002728227,0.0006298116,0.1154639],"study_design_scores_gemma":[0.02304707,0.02953658,0.603918,0.001359868,0.0003380693,0.000843545,0.004051282,0.002343077,0.3245859,0.006274418,0.002871483,0.0008307484],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970458,0.001415737,0.000100057,0.0002755007,0.00004420551,0.0007370788,0.00003058168,0.00002218448,0.000328889],"genre_scores_gemma":[0.9970713,0.00061103,0.001586805,0.00009114018,0.00004710194,0.00008493302,0.00001396212,0.0000155723,0.0004781884],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2067917,"threshold_uncertainty_score":0.3075334,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01736502105976898,"score_gpt":0.3025096314566336,"score_spread":0.2851446103968646,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}