{"id":"W2964731633","doi":"10.1101/721480","title":"Bivalent and Broad Chromatin Domains Regulate Pro-metastatic Drivers in Melanoma","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Cancer Institute; University of Texas MD Anderson Cancer Center; National Institutes of Health","keywords":"H3K4me3; Bivalent chromatin; Biology; Epigenetics; Epigenome; Chromatin; Microphthalmia-associated transcription factor; Cancer research; Neuroblastoma RAS viral oncogene homolog; SNAI1; Bivalent (engine); Genetics; Enhancer; Carcinogenesis; Histone; Metastasis; PRC2; Transcription factor; Promoter; Chromatin remodeling; DNA methylation; Cancer; Histone H3; Epithelial–mesenchymal transition; Gene expression; Gene; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008034832,0.0001109128,0.00008186873,0.0002446355,0.0001119553,0.0001840748,0.00008859239,0.0001073711,0.001292336],"category_scores_gemma":[0.0001037294,0.0001119825,0.0001078841,0.0001077219,0.0001239427,0.0001019706,0.0002164014,0.0001831646,0.0002560343],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001383128,"about_ca_system_score_gemma":0.00006450923,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003792929,"about_ca_topic_score_gemma":0.0009586525,"domain_scores_codex":[0.9999278,0.000006911933,0.000005206595,0.00002288908,0.00002160275,0.00001558856],"domain_scores_gemma":[0.9998893,0.00001120568,0.0000441814,0.00001016571,0.0000128459,0.00003224028],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004745897,0.000004387218,0.004998717,0.000008477853,0.000004834378,0.00002615931,0.000008296008,0.00005285248,0.9941517,0.00005728489,0.00001182517,0.0006280672],"study_design_scores_gemma":[0.00001283981,0.000272944,0.3600703,0.000007097956,0.00003415973,0.001479389,0.0001085696,0.00239906,0.6329111,0.0004012029,0.002292152,0.0000112567],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979447,0.0003042519,0.001030495,0.00001254808,0.000002393933,0.000004437828,0.0001835427,0.00002362148,0.0004941057],"genre_scores_gemma":[0.9989092,0.00005269446,0.0002756917,0.000008047763,0.000001015826,0.000003018389,0.0001465878,0.000004213565,0.0005995044],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001292336,"threshold_uncertainty_score":0.004323363,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007216544600795982,"score_gpt":0.2062065692769241,"score_spread":0.1989900246761281,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}