{"id":"W2964763129","doi":"10.1101/19002378","title":"Nonlinear biomarker interactions in conversion from Mild Cognitive Impairment to Alzheimer’s disease","year":2019,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Engineering and Physical Sciences Research Council; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Genentech; National Institutes of Health; IXICO; H. Lundbeck A/S; Servier; Eisai; Imperial College London; National Institute on Aging; National Institute for Health and Care Research; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University of Southern California; Eli Lilly and Company; U.S. Department of Defense; Medical Research Council; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; UK Dementia Research Institute; Novartis Pharmaceuticals Corporation; UK Research and Innovation; Bristol-Myers Squibb; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Biomarker; Alzheimer's Disease Neuroimaging Initiative; Context (archaeology); Neuroimaging; Disease; Oncology; Psychology; Neurodegeneration; Dementia; Neuroscience; Internal medicine; Cognition; Alzheimer's disease; Medicine; Biology; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003395337,0.0006523519,0.0006850002,0.001013909,0.0003817058,0.001168771,0.0004686462,0.0006568453,0.0008418077],"category_scores_gemma":[0.01044487,0.0003095141,0.001034992,0.0006776162,0.0006162528,0.0005456697,0.001090518,0.0009854072,0.0001574801],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005702869,"about_ca_system_score_gemma":0.0005777043,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01275256,"about_ca_topic_score_gemma":0.009238236,"domain_scores_codex":[0.9990425,0.0004925169,0.00006612403,0.0001439409,0.000145364,0.0001095928],"domain_scores_gemma":[0.9960652,0.002420778,0.0007455577,0.0002665455,0.0002961153,0.0002058153],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009926854,0.000223827,0.9781747,0.00003039244,0.0004619921,0.0003170776,0.0004076551,0.01003499,0.00163637,0.0001697413,0.0001085847,0.007442039],"study_design_scores_gemma":[0.00002611353,0.000438677,0.9095398,0.00001758387,0.0001784655,0.0002847169,0.0003307587,0.08580486,0.001024084,0.002148458,0.0001770824,0.00002940618],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987597,0.00007819014,0.0008977737,0.00004952222,0.000003634423,0.000008650185,0.00006489396,0.00001112699,0.0001264191],"genre_scores_gemma":[0.9996368,0.00001664858,0.0002266376,0.00000663505,0.000001991976,0.000003342408,0.00005963697,0.00000110119,0.00004715311],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01275256,"threshold_uncertainty_score":0.02535665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05914029563356365,"score_gpt":0.3726354257021437,"score_spread":0.31349513006858,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}