{"id":"W2964771088","doi":"10.1101/702001","title":"Immune landscapes predict chemotherapy resistance and immunotherapy response in acute myeloid leukemia","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Qatar National Research Fund; John and Lucille Van Geest Foundation; Fonds National de la Recherche Luxembourg","keywords":"Immunotherapy; Myeloid leukemia; Immune system; Immunology; Myeloid; Chemotherapy; Disease; Leukemia; Bone marrow; Medicine; Biology; Cancer research; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.002497949,0.0009799483,0.001664336,0.0009551104,0.0001414633,0.0002276669,0.0008034712,0.001232321,0.0001120592],"category_scores_gemma":[0.0003694873,0.0009734869,0.0002670012,0.0009052717,0.0002812878,0.000217693,0.0005856394,0.002635231,0.00009157584],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002629684,"about_ca_system_score_gemma":0.004155175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001143711,"about_ca_topic_score_gemma":0.000006739614,"domain_scores_codex":[0.994708,0.0004915485,0.001064829,0.001703891,0.0008803254,0.001151411],"domain_scores_gemma":[0.9955328,0.0003625544,0.0004890217,0.002735212,0.0004830356,0.000397443],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0166079,0.0001620934,0.02307143,0.000889253,0.0008305926,0.0005847987,0.00009024589,0.00002975423,0.9565462,0.00005725619,0.001119363,0.00001110762],"study_design_scores_gemma":[0.0101412,0.0004171571,0.7938244,0.002192642,0.0001592022,4.906148e-7,0.00001264234,0.0009393916,0.1725969,0.000003513146,0.01854111,0.001171342],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9825662,0.01141725,0.0002153431,0.00219132,0.0004599058,0.00246253,0.0002501108,0.0003945047,0.0000428515],"genre_scores_gemma":[0.9802026,0.01331086,0.004349313,0.0006848482,0.0003424528,0.000379085,0.000002165155,0.000380622,0.0003480889],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7839493,"threshold_uncertainty_score":0.9996657,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008973786963714054,"score_gpt":0.243629072927788,"score_spread":0.2346552859640739,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}