{"id":"W2964823446","doi":"10.1182/blood.v130.suppl_1.3100.3100","title":"A Phase 1b Study to Assess the Combination of Selinexor and Daratumumab in Patients with Relapsed / Refractory Multiple Myeloma Previously Exposed to Proteasome Inhibitors (PI) and Immunomodulatory Drugs (IMiDs)","year":2017,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Hôpital Maisonneuve-Rosemont; Vancouver General Hospital; CancerCare Manitoba; University of Toronto; Royal Victoria Hospital; Dalhousie University","funders":"","keywords":"Daratumumab; Medicine; Internal medicine; Regimen; Phases of clinical research; Pomalidomide; Lenalidomide; Clinical endpoint; Carfilzomib; Multiple myeloma; Adverse effect; Oncology; Nausea; Neutropenia; Gastroenterology; Clinical trial; Toxicity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00265224,0.001865606,0.002485255,0.0004981269,0.0005004384,0.001060363,0.0008506111,0.001399752,0.004646479],"category_scores_gemma":[0.001047914,0.0008710328,0.001972992,0.0003925904,0.001067207,0.0009104715,0.0004173184,0.003674548,0.001264164],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009971234,"about_ca_system_score_gemma":0.001650943,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006723631,"about_ca_topic_score_gemma":0.001630528,"domain_scores_codex":[0.9992506,0.0003703937,0.00003863801,0.0001383151,0.00007202535,0.00012998],"domain_scores_gemma":[0.9989457,0.0001409013,0.0001858064,0.00007568693,0.00006502507,0.0005869707],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7431012,0.149628,0.0100056,0.0006819167,0.001555462,0.0003190552,0.0002458761,0.001933836,0.04348384,0.0002030687,0.002777786,0.04606438],"study_design_scores_gemma":[0.3776909,0.6093047,0.009200046,0.0000158517,0.0002670202,0.0001445057,0.00002597749,0.0005139216,0.001595138,0.00007628018,0.001149636,0.00001602415],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921746,0.00121377,0.0004056978,0.0004436916,0.0001316073,0.003463869,0.0009985085,0.00006365425,0.00110462],"genre_scores_gemma":[0.9886008,0.000936428,0.0016568,0.0008785416,0.0002332721,0.003389705,0.001793794,0.00002322932,0.002487419],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004646479,"threshold_uncertainty_score":0.015544,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02393189601697607,"score_gpt":0.3035758967366704,"score_spread":0.2796440007196943,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}