{"id":"W2964859585","doi":"10.1002/jbmr.3843","title":"Burosumab Improved Histomorphometric Measures of Osteomalacia in Adults with X-Linked Hypophosphatemia: A Phase 3, Single-Arm, International Trial","year":2019,"lang":"en","type":"article","venue":"Journal of Bone and Mineral Research","topic":"Parathyroid Disorders and Treatments","field":"Medicine","cited_by":136,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Children's Hospital","funders":"National Center for Advancing Translational Sciences; Kyowa Hakko Kirin; Ultragenyx Pharmaceutical","keywords":"Osteomalacia; Osteoid; Hypophosphatemia; Medicine; Internal medicine; Bone remodeling; Urology; Bone resorption; Endocrinology; Osteoporosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008723505,0.0001144389,0.0005042684,0.001060966,0.00002316738,0.00002100124,0.00007523644,0.00008027922,0.00002818275],"category_scores_gemma":[0.0004688935,0.0000764914,0.00009082213,0.0005859444,0.00008848578,0.0001412556,0.00003403724,0.000396006,0.000003657685],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000158525,"about_ca_system_score_gemma":0.0002996224,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001985252,"about_ca_topic_score_gemma":0.0000440021,"domain_scores_codex":[0.9980929,0.00007307803,0.0005639676,0.000163059,0.000863053,0.0002439479],"domain_scores_gemma":[0.9986055,0.0001369135,0.0002660709,0.0001226194,0.0007113467,0.0001575235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5618795,0.0116694,0.03970007,0.000101784,0.0004201931,0.001334485,0.0008526332,0.000005242255,0.3622196,0.00003493682,0.003389647,0.0183925],"study_design_scores_gemma":[0.8596832,0.08954621,0.03331964,0.0006169628,0.0001495271,0.0008509448,0.001064471,0.000581403,0.009933288,0.0001009629,0.003888888,0.000264575],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883261,0.009506621,0.000005500675,0.0003814959,0.0001321803,0.0005351877,0.000006831566,0.000002219514,0.001103817],"genre_scores_gemma":[0.9973165,0.0007350247,0.0002814554,0.00001976705,0.00008920695,0.000007899819,0.000007568934,0.00001281788,0.001529786],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3522864,"threshold_uncertainty_score":0.3119229,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06491439628370645,"score_gpt":0.3570369156777951,"score_spread":0.2921225193940887,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}