{"id":"W2964881489","doi":"10.1093/nar/gkz640","title":"Structural and phenotypic analysis of Chikungunya virus RNA replication elements","year":2019,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Medical Research Council; Medical Research Council Canada; Royal Society","keywords":"Biology; Alphavirus; Replicon; Viral replication; Genetics; Genome; Chikungunya; Origin of replication; Reverse genetics; Virus; Virology; RNA virus; RNA; Semliki Forest virus; Togaviridae; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005886843,0.00009500063,0.0003410683,0.0004022435,0.00007328691,0.00002594155,0.0001561973,0.00006752762,0.0009685046],"category_scores_gemma":[0.0001792346,0.00007748381,0.0001192667,0.0008852932,0.00009602199,0.00006910128,0.0001073361,0.000210857,0.00006605617],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005811992,"about_ca_system_score_gemma":0.00007111426,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002049951,"about_ca_topic_score_gemma":0.00001833674,"domain_scores_codex":[0.9981918,0.00009080214,0.0002838718,0.0004222207,0.0007020755,0.0003092642],"domain_scores_gemma":[0.9984964,0.00006846926,0.00007234518,0.000895999,0.0002959516,0.0001708821],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001027111,0.0001239926,0.737147,0.0001770387,0.001451293,0.000005886614,0.0003272488,0.00001177863,0.1555163,0.002488979,0.0004957051,0.1012277],"study_design_scores_gemma":[0.001346704,0.0003227076,0.9714369,0.00002382686,0.0004945102,0.000001295843,0.0002028738,0.0230153,0.001770542,0.0001796994,0.001126726,0.00007889579],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965221,0.0005977554,0.00001149352,0.0003283995,0.0000264449,0.0005347668,0.00003386648,0.00003743766,0.001907723],"genre_scores_gemma":[0.9987875,0.00008339043,0.000128512,0.0000982486,0.00006028751,0.00001985727,0.0000551431,0.00002574674,0.000741359],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2342899,"threshold_uncertainty_score":0.9999447,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03105283016254816,"score_gpt":0.3654122115093228,"score_spread":0.3343593813467747,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}