{"id":"W2964946855","doi":"10.1016/j.jaad.2019.07.083","title":"Efficacy and safety of ingenol mebutate gel in field treatment of actinic keratosis on full face, balding scalp, or approximately 250 cm2 on the chest: A phase 3 randomized controlled trial","year":2019,"lang":"en","type":"article","venue":"Journal of the American Academy of Dermatology","topic":"Nonmelanoma Skin Cancer Studies","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"Bellus Health (Canada)","funders":"Cilag; LEO Pharma; Dermira; Astellas Pharma Canada; Genentech; Valeant Pharmaceuticals International; Celgene; Novartis; Galderma; Eli Lilly and Company; Endo International; Australian Wool Innovation; AbbVie; Sanofi; Regeneron Pharmaceuticals; Abbott Laboratories; Merck; GlaxoSmithKline; Amgen","keywords":"Medicine; Actinic keratosis; Scalp; Randomized controlled trial; Clinical endpoint; Dermatology; Randomization; Blinding; Patient satisfaction; Surgery; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000670721,0.0002376024,0.003719011,0.0002514844,0.00004370534,0.000003806539,0.0002285129,0.00009794365,0.00002817814],"category_scores_gemma":[0.001121368,0.0001046834,0.000499338,0.0002640295,0.0005483532,0.00003566968,0.00005411558,0.0004311808,0.000001276701],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000852146,"about_ca_system_score_gemma":0.0001245173,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001928317,"about_ca_topic_score_gemma":0.0000015676,"domain_scores_codex":[0.9969407,0.0008016803,0.001527718,0.0001683198,0.0003321809,0.0002294311],"domain_scores_gemma":[0.9901274,0.006481776,0.003094796,0.000184697,0.00004994897,0.00006132379],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.984525,0.0007893966,0.002159433,0.000070795,0.001754089,0.0000158737,0.001121788,0.00002249614,0.005339388,0.00007669397,0.00006761758,0.004057452],"study_design_scores_gemma":[0.9429883,0.006107692,0.002898198,0.0004709869,0.0008648376,0.000551969,0.0006501161,0.0002748,0.04485608,0.00005052785,0.0001839666,0.0001025752],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9760181,0.0007145472,0.0000176146,0.02021212,0.0001265532,0.002630933,0.000006361341,0.000003107963,0.0002706642],"genre_scores_gemma":[0.9966371,0.002366969,0.0002141192,0.0006364203,0.00005463725,0.00004832908,1.900858e-7,0.00001581703,0.00002640436],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04153672,"threshold_uncertainty_score":0.4268864,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02875779724342187,"score_gpt":0.3479376942308842,"score_spread":0.3191798969874623,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}