{"id":"W2964946855","doi":"10.1016/j.jaad.2019.07.083","title":"Efficacy and safety of ingenol mebutate gel in field treatment of actinic keratosis on full face, balding scalp, or approximately 250 cm2 on the chest: A phase 3 randomized controlled trial","year":2019,"lang":"en","type":"article","venue":"Journal of the American Academy of Dermatology","topic":"Nonmelanoma Skin Cancer Studies","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"Bellus Health (Canada)","funders":"Cilag; LEO Pharma; Dermira; Astellas Pharma Canada; Genentech; Valeant Pharmaceuticals International; Celgene; Novartis; Galderma; Eli Lilly and Company; Endo International; Australian Wool Innovation; AbbVie; Sanofi; Regeneron Pharmaceuticals; Abbott Laboratories; Merck; GlaxoSmithKline; Amgen","keywords":"Medicine; Actinic keratosis; Scalp; Randomized controlled trial; Clinical endpoint; Dermatology; Randomization; Blinding; Patient satisfaction; Surgery; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001537427,0.002246534,0.004436909,0.0004709182,0.0005831117,0.001499424,0.00139373,0.002282324,0.008100987],"category_scores_gemma":[0.001722064,0.0009124972,0.002894007,0.0004987966,0.001544416,0.001319253,0.0003708694,0.004273484,0.001009038],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000870168,"about_ca_system_score_gemma":0.001048315,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001476299,"about_ca_topic_score_gemma":0.002626659,"domain_scores_codex":[0.9993389,0.0003300695,0.00003819531,0.0001361323,0.00004908811,0.0001075519],"domain_scores_gemma":[0.9989302,0.0004349879,0.0002184037,0.00008149997,0.00007157416,0.0002633366],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9857882,0.004648258,0.0002396999,0.0007334367,0.0009863931,0.00002737679,0.00003931633,0.0001487566,0.001239564,0.00006575944,0.0003484421,0.00573481],"study_design_scores_gemma":[0.9667163,0.03132946,0.0006684462,0.00003875327,0.0005693056,0.00001201637,0.00002170553,0.0001935204,0.00015352,0.00007702762,0.000209052,0.00001091123],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9778347,0.01222226,0.000933337,0.0008385642,0.0008899057,0.003842018,0.0008845847,0.0001373843,0.00241725],"genre_scores_gemma":[0.984476,0.004936395,0.001264281,0.00130872,0.0006516642,0.003178909,0.0006367578,0.00002990539,0.003517279],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008100987,"threshold_uncertainty_score":0.0271005,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02875779724342187,"score_gpt":0.3479376942308842,"score_spread":0.3191798969874623,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}