{"id":"W2964987874","doi":"10.3389/fpls.2019.01058","title":"Molecular Origins of Functional Diversity in Benzylisoquinoline Alkaloid Methyltransferases","year":2019,"lang":"en","type":"review","venue":"Frontiers in Plant Science","topic":"Berberine and alkaloids research","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Benzylisoquinoline; Biology; Evolutionary biology; Function (biology); Computational biology; Genetics; Biosynthesis; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008753439,0.0002694644,0.001539243,0.00170314,0.00006624299,0.00001474923,0.0005764411,0.0001778962,0.00005226113],"category_scores_gemma":[0.0001554522,0.000218542,0.0002356308,0.002227292,0.000516352,0.0001660766,0.0003286358,0.000678214,0.00001461859],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000634724,"about_ca_system_score_gemma":0.001548482,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004446879,"about_ca_topic_score_gemma":0.00002972203,"domain_scores_codex":[0.9971997,0.00008183427,0.0005171774,0.0006267693,0.001053607,0.00052096],"domain_scores_gemma":[0.9991395,0.00009199031,0.000107201,0.0004155849,0.00008959213,0.0001560758],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004363763,0.001119433,0.03424387,0.04116871,0.0003223201,0.001599598,0.0003420595,0.0001924055,0.000833376,0.002294097,0.006067292,0.9113805],"study_design_scores_gemma":[0.00154314,0.0003533967,0.001439191,0.01346967,0.0003720715,0.0001682016,0.0001019112,0.0004391433,0.0004488987,0.00008397175,0.98102,0.0005603801],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003793051,0.992463,0.0008662969,0.00003403602,0.0007851472,0.0008888374,0.0003905002,0.00001275521,0.0007663818],"genre_scores_gemma":[0.001975368,0.9963936,0.001143971,0.00003618751,0.00004272814,0.00001605583,0.0002149075,0.00001551659,0.0001616737],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9749528,"threshold_uncertainty_score":0.8911883,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08675324174748399,"score_gpt":0.3456307446421486,"score_spread":0.2588775028946646,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}