{"id":"W2965032871","doi":"10.1212/wnl.92.15_supplement.p3.2-072","title":"Phase 2 AFFINITY Trial Evaluates Opicinumab in a Targeted Population of Patients With Relapsing Multiple Sclerosis: Rationale, Design and Baseline Characteristics (P3.2-072)","year":2019,"lang":"en","type":"article","venue":"Neurology","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; NeuroRx Research (Canada)","funders":"","keywords":"Multiple sclerosis; Baseline (sea); Medicine; Population; Oncology; Clinical trial; Internal medicine; Physical medicine and rehabilitation; Physical therapy; Immunology; Environmental health; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00152615,0.0009638761,0.00109084,0.0001581344,0.0005051004,0.0007668418,0.0005162169,0.0009338827,0.006535116],"category_scores_gemma":[0.00147923,0.0003616636,0.0005909269,0.000244305,0.0003922455,0.0007422832,0.0003384494,0.002086447,0.001323544],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000519519,"about_ca_system_score_gemma":0.001328623,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006221498,"about_ca_topic_score_gemma":0.003371079,"domain_scores_codex":[0.9996014,0.000194758,0.00002176875,0.00006343922,0.00004729191,0.00007123309],"domain_scores_gemma":[0.9994239,0.0001064599,0.0001197575,0.00003659275,0.00007955503,0.0002338128],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7766229,0.0187797,0.01915786,0.001769322,0.002224028,0.0003068806,0.0002623764,0.001188828,0.02999165,0.001217668,0.01558125,0.1328975],"study_design_scores_gemma":[0.7112027,0.2110907,0.05006883,0.0002105872,0.001965184,0.0006071991,0.0001489762,0.001442895,0.004006758,0.001439388,0.017744,0.00007271024],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9676551,0.004860694,0.002022964,0.002559385,0.000370748,0.01023191,0.004514168,0.0001599688,0.007625051],"genre_scores_gemma":[0.9738592,0.0017174,0.003220494,0.00349405,0.0005237827,0.009003031,0.002679667,0.00003950629,0.005462766],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006535116,"threshold_uncertainty_score":0.02186215,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01825439712905259,"score_gpt":0.2364434683225569,"score_spread":0.2181890711935043,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}