{"id":"W2965080989","doi":"10.1186/s12885-019-5914-8","title":"Selective ERK1/2 agonists isolated from Melia azedarach with potent anti-leukemic activity","year":2019,"lang":"en","type":"article","venue":"BMC Cancer","topic":"Phytochemical compounds biological activities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"Ministry of National Defense, People's Republic of China; National Natural Science Foundation of China; National Science Foundation","keywords":"MAPK/ERK pathway; Kinase; Melia azedarach; Cell growth; Docking (animal); Biology; Cancer research; Cell culture; Apoptosis; Chemistry; Cell biology; Biochemistry; Medicine; Botany; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004639916,0.0003423695,0.0002222425,0.0002568347,0.0001204102,0.0001223529,0.0001300411,0.0001149079,0.001508459],"category_scores_gemma":[0.00003957223,0.00007585093,0.0002838127,0.0001245106,0.00008767991,0.0001137326,0.0001219841,0.0002681485,0.0003202259],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001473965,"about_ca_system_score_gemma":0.0001267837,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000246355,"about_ca_topic_score_gemma":0.000705849,"domain_scores_codex":[0.9999804,0.000002321215,0.000001872427,0.000004829456,0.000005935689,0.000004535444],"domain_scores_gemma":[0.9999846,0.000002155692,0.0000044042,0.000001290437,0.000002573879,0.000004881217],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000259533,0.00008124487,0.0002831204,0.000253841,0.00001875565,0.0001015259,0.000009511718,0.0004847769,0.9914219,0.0001435434,0.0001347998,0.006807414],"study_design_scores_gemma":[0.00034386,0.002282855,0.006269961,0.00003366075,0.0001126804,0.0006029018,0.00003118965,0.002425606,0.9758287,0.0001815757,0.01186883,0.00001815039],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9811519,0.009030776,0.00304574,0.0001655326,0.00004541931,0.00009757945,0.0008491586,0.0001129176,0.005501099],"genre_scores_gemma":[0.9906904,0.003253195,0.003251736,0.0001184797,0.00001237138,0.00004357056,0.0009814673,0.000008586051,0.001640231],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001508459,"threshold_uncertainty_score":0.005046248,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01026374783629176,"score_gpt":0.2432738761606642,"score_spread":0.2330101283243725,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}