{"id":"W2965270240","doi":"10.1016/j.ccell.2019.07.002","title":"Protein Kinase Cι and Wnt/β-Catenin Signaling: Alternative Pathways to Kras/Trp53-Driven Lung Adenocarcinoma","year":2019,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":false,"ca_institutions":"Memorial University of Newfoundland","funders":"National Cancer Institute; National Institutes of Health; Mayo Clinic","keywords":"Wnt signaling pathway; Cancer research; Biology; AXIN2; Adenocarcinoma; Carcinogenesis; Protein kinase C; Signal transduction; KRAS; Cell biology; Genetics; Gene; Cancer; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001322083,0.0002943301,0.0002412541,0.00004906829,0.0000829181,0.00005258955,0.0003143451,0.0001607744,0.0003586419],"category_scores_gemma":[0.00001237776,0.0002838569,0.00008050073,0.0001108406,0.00005536035,0.00001181276,0.0002221628,0.0001279913,0.0000693529],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001021279,"about_ca_system_score_gemma":0.00019767,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001383998,"about_ca_topic_score_gemma":0.00003261256,"domain_scores_codex":[0.9983568,0.00004908601,0.0002496919,0.0007078675,0.000213465,0.0004231116],"domain_scores_gemma":[0.9992701,0.00001110511,0.0001177687,0.0002570772,0.0001383548,0.0002055554],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001479664,0.00003041084,0.01267353,0.0000899053,0.00006320418,0.000009265335,0.0005402504,0.0004771194,0.9830841,0.00004389118,0.001953131,0.0008872706],"study_design_scores_gemma":[0.0009146486,0.0002980853,0.001212715,0.0001032764,0.00002787802,0.000002721562,0.0001812635,0.0001967529,0.987851,0.00005869659,0.00867713,0.000475822],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889931,0.007669345,0.0003216196,0.0001310497,0.000388546,0.0007596572,0.00003833215,0.00002594048,0.001672391],"genre_scores_gemma":[0.9919434,0.0002082389,0.0009335371,0.0004943599,0.0004097877,0.0002949531,0.00006284228,0.00005725387,0.005595669],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01146082,"threshold_uncertainty_score":0.9999614,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01163219480309385,"score_gpt":0.23076609095373,"score_spread":0.2191338961506362,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}