{"id":"W2965395580","doi":"10.1021/acs.bioconjchem.9b00436","title":"A Reactive Antibody Platform for One-Step Production of Antibody–Drug Conjugates through a Diels–Alder Reaction with Maleimide","year":2019,"lang":"en","type":"article","venue":"Bioconjugate Chemistry","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; National Institutes of Health","keywords":"Maleimide; Chemistry; Bioconjugation; Conjugate; Combinatorial chemistry; Covalent bond; Diels–Alder reaction; Antibody; In vivo; Drug; Biochemistry; Organic chemistry; Catalysis; Pharmacology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002524155,0.0003384761,0.0006412811,0.00006020912,0.0001068787,0.000023439,0.0001502927,0.0001800648,0.0001907676],"category_scores_gemma":[0.00009895398,0.0002612148,0.0002023035,0.0002370478,0.0002836821,0.0003060774,0.00006731857,0.0003569785,0.00004544917],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009499044,"about_ca_system_score_gemma":0.0002116493,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003092109,"about_ca_topic_score_gemma":0.000008141832,"domain_scores_codex":[0.9978248,0.00001575023,0.0004607268,0.0006745299,0.000527859,0.0004963642],"domain_scores_gemma":[0.998373,0.0001324626,0.000309702,0.0005072707,0.0005246571,0.0001528648],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005633483,0.0004171335,0.01556373,0.003094567,0.0004065181,0.00001435481,0.0002549613,0.000001759057,0.973435,0.0001811525,0.0006237464,0.0003735608],"study_design_scores_gemma":[0.002200178,0.0005051388,0.007103723,0.0009683262,0.0001699886,0.0002192179,0.0006972877,0.00008475715,0.9701541,0.0001701688,0.01739429,0.0003328262],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869601,0.000346606,0.00006169362,0.001530615,0.0001560081,0.001562336,0.00009642712,0.00007146574,0.009214771],"genre_scores_gemma":[0.9783792,0.000364769,0.002009908,0.0001183373,0.0004740335,0.00009125834,0.0009899855,0.00006187618,0.01751064],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01677054,"threshold_uncertainty_score":0.999984,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02735769362625689,"score_gpt":0.3188144824062977,"score_spread":0.2914567887800408,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}