{"id":"W2965395580","doi":"10.1021/acs.bioconjchem.9b00436","title":"A Reactive Antibody Platform for One-Step Production of Antibody–Drug Conjugates through a Diels–Alder Reaction with Maleimide","year":2019,"lang":"en","type":"article","venue":"Bioconjugate Chemistry","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; National Institutes of Health","keywords":"Maleimide; Chemistry; Bioconjugation; Conjugate; Combinatorial chemistry; Covalent bond; Diels–Alder reaction; Antibody; In vivo; Drug; Biochemistry; Organic chemistry; Catalysis; Pharmacology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002620759,0.000424517,0.0001878476,0.0002210586,0.0001060004,0.0001872367,0.0003230356,0.0002949577,0.0008657067],"category_scores_gemma":[0.0001232957,0.0002110506,0.0002023973,0.0001542911,0.0001706701,0.0002327119,0.0002522146,0.0004960076,0.000557197],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002234504,"about_ca_system_score_gemma":0.0002163884,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000147332,"about_ca_topic_score_gemma":0.0003166648,"domain_scores_codex":[0.9998494,0.00001996661,0.00001350915,0.00003842862,0.00005487302,0.00002382708],"domain_scores_gemma":[0.9999343,0.000009882802,0.00002200394,0.00001238714,0.00000908878,0.00001225937],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001584924,0.00002320611,0.00004805918,0.00005819323,0.000005223508,0.00004943394,0.00001554676,0.0001491205,0.9957176,0.0006294241,0.00007259704,0.003215814],"study_design_scores_gemma":[0.000007649106,0.0002042118,0.0002680197,0.00000239777,0.000007327849,0.0002377183,0.000002672463,0.0008149031,0.9939428,0.00005595029,0.004450166,0.000006124498],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.761439,0.00429723,0.2225867,0.0003318345,0.0001511483,0.0004617015,0.0004937798,0.0008847982,0.009353848],"genre_scores_gemma":[0.9292995,0.001727368,0.06299429,0.0001395379,0.00003098617,0.0001482794,0.0003679897,0.0000383547,0.00525367],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008657067,"threshold_uncertainty_score":0.00289607,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02735769362625689,"score_gpt":0.3188144824062977,"score_spread":0.2914567887800408,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}