{"id":"W2965412560","doi":"10.1371/journal.ppat.1007982","title":"The host cell secretory pathway mediates the export of Leishmania virulence factors out of the parasitophorous vacuole","year":2019,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer; McGill University; Institut National de la Recherche Scientifique","funders":"Canadian Institutes of Health Research; McMaster University","keywords":"Cell biology; Lipophosphoglycan; Biology; Golgi apparatus; Endoplasmic reticulum; Virulence; Vacuole; Effector; Phagosome; Secretion; Leishmania; Virulence factor; Secretory pathway; Cytoplasm; Phagocytosis; Leishmania donovani; Immunology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006947949,0.0002731226,0.0005378922,0.0000529838,0.0002896726,0.00002077763,0.0008012421,0.0001089112,0.00009180495],"category_scores_gemma":[0.0006895718,0.0001180638,0.0003111792,0.0002573516,0.0005732668,0.00006829414,0.0003856528,0.000447078,0.00007964623],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000730972,"about_ca_system_score_gemma":0.0002725194,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005449272,"about_ca_topic_score_gemma":0.00006696099,"domain_scores_codex":[0.997062,0.0002654578,0.0005506085,0.000353051,0.00125764,0.0005112353],"domain_scores_gemma":[0.9966139,0.001093554,0.0003924591,0.001403196,0.0003856283,0.0001112597],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00006391489,0.000202101,0.4650844,0.0001672892,0.0001724446,0.00001073183,0.004101484,0.000001767866,0.5293673,0.00008242195,0.0005130753,0.0002330734],"study_design_scores_gemma":[0.0004343578,0.00032191,0.5964748,0.0001186929,0.0001171849,0.000003665082,0.004931319,0.00005159324,0.3951722,0.00004537225,0.002195314,0.0001336313],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902632,0.001789464,0.00000348273,0.0005636237,0.0004603159,0.001230424,0.0001386848,0.00003128986,0.005519474],"genre_scores_gemma":[0.9968902,0.0009302949,0.00003085691,0.00009486599,0.0001278748,0.00005864304,0.000006439994,0.00004405918,0.001816716],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1341951,"threshold_uncertainty_score":0.4814503,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02561223333500106,"score_gpt":0.2575296534157049,"score_spread":0.2319174200807039,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}