{"id":"W2965440897","doi":"10.1152/ajpcell.00250.2019","title":"Activated cholangiocytes release macrophage-polarizing extracellular vesicles bearing the DAMP S100A11","year":2019,"lang":"en","type":"article","venue":"American Journal of Physiology-Cell Physiology","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Institutes of Health; School of Medicine, New York University; York University","keywords":"Proinflammatory cytokine; Cholangiocyte; Cell biology; Rage (emotion); Damp; Chemokine; TRADD; Biology; Cytokine; Chemistry; Inflammation; Immunology; Programmed cell death; Biochemistry; Endocrinology; Apoptosis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004617979,0.000429121,0.0006857351,0.0001212311,0.0001888468,0.00002977683,0.001118252,0.0001964183,0.0001258056],"category_scores_gemma":[0.0001473901,0.0003241122,0.0004986344,0.0003033239,0.0008704644,0.00003159384,0.000360896,0.000745486,0.0001130704],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004629643,"about_ca_system_score_gemma":0.0002007517,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003628278,"about_ca_topic_score_gemma":0.000001251696,"domain_scores_codex":[0.9970284,0.0007131859,0.0007051099,0.0006251163,0.0002402427,0.0006879119],"domain_scores_gemma":[0.9971542,0.0001829541,0.001179036,0.001005578,0.0002384397,0.0002397539],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000892946,0.0002551056,0.0006597515,0.00003577561,0.0002336903,0.00001334062,0.0001084301,0.001775906,0.9939101,0.00004536557,0.0004996962,0.001569912],"study_design_scores_gemma":[0.001239127,0.001639123,0.02195202,0.00003417745,0.00009613377,0.00007984663,0.0006854432,0.0001284882,0.9668432,0.0003693043,0.006514013,0.0004191074],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952813,0.003512495,0.0001013973,0.0001852055,0.0004238056,0.0002519905,0.00001310871,0.00002073197,0.0002099993],"genre_scores_gemma":[0.9971601,0.0003049942,0.0006687932,0.0006147586,0.0007532758,0.000009071933,0.00005606687,0.00008417564,0.000348766],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02706687,"threshold_uncertainty_score":0.9999211,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005004654334200762,"score_gpt":0.2217401865822444,"score_spread":0.2167355322480436,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}