{"id":"W2965631396","doi":"10.1089/nat.2019.0792","title":"Effect of Sugar 2′,4′-Modifications on Gene Silencing Activity of siRNA Duplexes","year":2019,"lang":"en","type":"article","venue":"Nucleic Acid Therapeutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; California HIV/AIDS Research Program","keywords":"Gene silencing; Chemistry; Gene; Sugar; Cell biology; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001570807,0.000131648,0.0001953516,0.00004188945,0.00002643052,0.000005401988,0.0002121087,0.0001293657,0.00003535732],"category_scores_gemma":[0.00001453934,0.0001119454,0.0001200505,0.00006794413,0.00006296617,0.000003988444,0.00004508479,0.00007817079,0.00003069263],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009893178,"about_ca_system_score_gemma":0.00003321385,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001184827,"about_ca_topic_score_gemma":0.000002294685,"domain_scores_codex":[0.9992751,0.00007867838,0.0001705676,0.0002102977,0.0001261619,0.0001392242],"domain_scores_gemma":[0.9992381,0.00003842473,0.0001394649,0.0004815821,0.00007584456,0.0000266045],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002809359,0.00007244156,0.001385312,0.00003755128,0.000101008,1.819561e-7,0.00007309832,0.0001136447,0.9873061,0.00004595912,0.00002774572,0.01055599],"study_design_scores_gemma":[0.000368445,0.001989629,0.002218841,0.00002156303,0.00003823562,0.000001621672,0.00002260682,0.0002563581,0.9945828,0.00001508614,0.0003798076,0.0001049999],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980893,0.0002704252,0.0002795271,0.00003072984,0.0001292624,0.0001705896,0.0000268646,0.000007159958,0.0009961769],"genre_scores_gemma":[0.9993498,0.0002257023,0.00008030603,0.00009566088,0.00004725434,0.000005062406,0.00001609806,0.00001880993,0.0001613226],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01045099,"threshold_uncertainty_score":0.4565,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01298300693552538,"score_gpt":0.269275570478272,"score_spread":0.2562925635427466,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}