{"id":"W2965633746","doi":"10.1073/pnas.1904108116","title":"Regulation of <i>CCL2</i> expression in human vascular endothelial cells by a neighboring divergently transcribed long noncoding RNA","year":2019,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Toronto General Hospital; University of Toronto; University Health Network","funders":"Ontario Ministry of Research and Innovation; Natural Sciences and Engineering Research Council of Canada; Scheme for Promotion of Academic and Research Collaboration; Hospital for Sick Children; Government of Canada; Vetenskapsrådet; Canadian Institutes of Health Research; Stockholms Läns Landsting; Svenska Sällskapet för Medicinsk Forskning; Canada Research Chairs","keywords":"Biology; Cell biology; Gene; Messenger RNA; RNA; Regulation of gene expression; CCL2; Gene expression; Enhancer; Chromatin; Non-coding RNA; Proinflammatory cytokine; Histone; Inflammation; Chemokine; Genetics; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001082423,0.0001722533,0.0001765659,0.000149933,0.0001787909,0.000332654,0.00008111238,0.0000998523,0.0005962856],"category_scores_gemma":[0.0001446384,0.00009133543,0.0002038363,0.0001922425,0.0001213782,0.00009216696,0.0001197002,0.0001844032,0.0002053692],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002206411,"about_ca_system_score_gemma":0.0001981285,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000855453,"about_ca_topic_score_gemma":0.001143538,"domain_scores_codex":[0.9998245,0.00002195409,0.00001422997,0.00006670314,0.00003641212,0.0000362498],"domain_scores_gemma":[0.9999168,0.00001297304,0.0000263472,0.000009930623,0.00001910831,0.0000148672],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005805608,0.000006944075,0.000402628,0.0000174895,0.000003146736,0.00002882574,0.00001823667,0.00002358659,0.9988514,0.00002776332,0.00002143749,0.0005404553],"study_design_scores_gemma":[0.00002911707,0.0003043212,0.04147581,0.0000100826,0.00003460315,0.0005284398,0.0001106389,0.00137875,0.9522691,0.00005348606,0.003788372,0.00001738557],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936575,0.001851977,0.002515946,0.00005422443,0.00002619231,0.00002036232,0.0006249089,0.00005590437,0.001192956],"genre_scores_gemma":[0.9950175,0.0006964827,0.002224965,0.000076103,0.00001650442,0.00004536272,0.001030278,0.00001621775,0.0008766229],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000855453,"threshold_uncertainty_score":0.001994789,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01685007887777762,"score_gpt":0.2814602677716657,"score_spread":0.2646101888938881,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}