{"id":"W2965636153","doi":"10.1016/j.jbior.2019.100638","title":"The TCR/CD3 complex in leukemogenesis and as a therapeutic target in T-cell acute lymphoblastic leukemia","year":2019,"lang":"en","type":"review","venue":"Advances in Biological Regulation","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"European Regional Development Fund; Fundação para a Ciência e a Tecnologia; Programa Operacional Temático Factores de Competitividade; Institut National de la Santé et de la Recherche Médicale; Conseil National de la Recherche Scientifique; Institute of Cancer Research; Institut National Du Cancer; Ligue Contre le Cancer; Institut Curie; University of Pittsburgh","keywords":"T-cell receptor; Biology; CD3; Thymocyte; T cell; Leukemia; Antigen; Major histocompatibility complex; Immunology; T-cell leukemia; Cell biology; Cancer research; Immune system; CD8","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008075404,0.0004027723,0.001429377,0.0003229331,0.00005700657,0.00003175913,0.0002759344,0.000493563,0.0002439649],"category_scores_gemma":[0.0001929664,0.0002268677,0.0001841244,0.0008147027,0.0003203548,0.00009896277,0.0001273858,0.0005021458,0.00005037758],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001386114,"about_ca_system_score_gemma":0.0003827108,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004018433,"about_ca_topic_score_gemma":0.00007912807,"domain_scores_codex":[0.9970759,0.0006071343,0.0007978595,0.000674391,0.0003175576,0.0005271865],"domain_scores_gemma":[0.9973604,0.001841095,0.0002400711,0.0004378005,0.00004204954,0.00007858798],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003767665,0.00005884016,0.002177279,0.001239036,0.00003256272,0.00003122399,0.00002906638,0.00008339796,0.0006127736,0.0002644774,0.000005571752,0.995089],"study_design_scores_gemma":[0.00190897,0.0005569929,0.01099813,0.002613134,0.00008533864,0.00007894079,0.00003288813,0.001143046,0.00002411925,0.003085867,0.97912,0.000352616],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.009483342,0.9868208,0.00003085344,0.00006462794,0.0001097927,0.002047971,0.000009396901,0.00002274105,0.001410455],"genre_scores_gemma":[0.01405322,0.9839698,0.0001973609,0.00008238755,0.00007587027,0.0002032159,0.0001860165,0.00003537823,0.001196738],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9947364,"threshold_uncertainty_score":0.9251395,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08073849367163725,"score_gpt":0.3894962577697001,"score_spread":0.3087577640980628,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}