{"id":"W2965657058","doi":"10.2139/ssrn.3277362","title":"Single Cell Proteomics Reveal that Temporal Changes in Transcription Factors Determine Cell-Fate","year":2018,"lang":"en","type":"article","venue":"SSRN Electronic Journal","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Stem Cell Network; University of Ottawa","funders":"","keywords":"Proteomics; Cell; Transcription factor; Cell fate determination; Computational biology; Biology; Transcription (linguistics); Cell biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001602369,0.0002176598,0.0004181391,0.0002270351,0.0002097775,0.001089178,0.0002613754,0.0004738376,0.002302234],"category_scores_gemma":[0.0002401309,0.0002536483,0.0002858946,0.0003002835,0.0002348327,0.0007901649,0.0002573193,0.0007075617,0.002370319],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004715219,"about_ca_system_score_gemma":0.000224801,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006053154,"about_ca_topic_score_gemma":0.002105896,"domain_scores_codex":[0.999878,0.000004889772,0.000008697082,0.00005658504,0.00003435117,0.00001747444],"domain_scores_gemma":[0.9998307,0.00004721289,0.0000375325,0.00002451513,0.00002797188,0.00003196284],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004451186,0.000004988456,0.0003135379,0.00001429255,0.000002755841,0.00002293134,0.000007934291,0.0000396769,0.9978789,0.0001177914,0.00007755244,0.001475234],"study_design_scores_gemma":[0.000008260275,0.00004442334,0.02487963,0.000004580694,0.00001508594,0.0002773693,0.0000683787,0.002301256,0.9693601,0.0005321366,0.002493921,0.00001480941],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9575121,0.002443611,0.02899559,0.0003442872,0.0001657224,0.00002836355,0.00466239,0.0004096609,0.005438134],"genre_scores_gemma":[0.9715443,0.001831061,0.01229611,0.0003679361,0.00004298556,0.0000447217,0.00331209,0.0002916349,0.01026916],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002302234,"threshold_uncertainty_score":0.007701695,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01806276161227443,"score_gpt":0.2206031858195734,"score_spread":0.202540424207299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}