{"id":"W2965691495","doi":"10.1016/j.oret.2019.07.006","title":"One-Time Intravitreal Injection of KVD001, a Plasma Kallikrein Inhibitor, in Patients with Central-Involved Diabetic Macular Edema and Reduced Vision","year":2019,"lang":"en","type":"article","venue":"Ophthalmology Retina","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Allergan; Alcon; Topcon Europe Medical; Santen; Novartis; Regeneron Pharmaceuticals; Bausch and Lomb; Valeant Pharmaceuticals International; Genentech; Bayer","keywords":"Diabetic macular edema; Medicine; Macular edema; Kallikrein; Ophthalmology; Edema; Retinal; Diabetic retinopathy; Diabetes mellitus; Internal medicine; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001941345,0.000238356,0.0006181293,0.0002176711,0.00004438766,0.00001124669,0.00007189859,0.0002700753,0.0002367453],"category_scores_gemma":[0.00006480081,0.0002161803,0.00006736558,0.0002912427,0.0001740858,0.0001188529,0.00005748812,0.0001990293,0.00002815709],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000815161,"about_ca_system_score_gemma":0.00008859245,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001491288,"about_ca_topic_score_gemma":0.000006385968,"domain_scores_codex":[0.9982456,0.0001220442,0.000454259,0.0004856765,0.0002800673,0.0004123471],"domain_scores_gemma":[0.9991128,0.0000967738,0.0002179154,0.0003054829,0.0001202801,0.0001467282],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001801849,0.0005582631,0.9810265,0.0001608072,0.0000650572,0.00004259767,0.000421465,0.00001484555,0.01470273,0.00004015954,0.00004612641,0.001119571],"study_design_scores_gemma":[0.005479207,0.003711439,0.9790796,0.0005102439,0.00009319863,0.0001533495,0.00005512024,0.0004573125,0.01010151,0.000129711,0.00001527556,0.0002140358],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976537,0.0001491955,0.00000108429,0.0001743882,0.0001699743,0.0008359163,0.000007951307,0.00003025529,0.0009775705],"genre_scores_gemma":[0.9988847,0.00001006721,0.0002919137,0.00002525235,0.0000623653,0.00001414015,0.0001560467,0.00003775232,0.0005177727],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004601222,"threshold_uncertainty_score":0.8815577,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006670926387441641,"score_gpt":0.228402585689818,"score_spread":0.2217316593023763,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}