{"id":"W2965691495","doi":"10.1016/j.oret.2019.07.006","title":"One-Time Intravitreal Injection of KVD001, a Plasma Kallikrein Inhibitor, in Patients with Central-Involved Diabetic Macular Edema and Reduced Vision","year":2019,"lang":"en","type":"article","venue":"Ophthalmology Retina","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Allergan; Alcon; Topcon Europe Medical; Santen; Novartis; Regeneron Pharmaceuticals; Bausch and Lomb; Valeant Pharmaceuticals International; Genentech; Bayer","keywords":"Diabetic macular edema; Medicine; Macular edema; Kallikrein; Ophthalmology; Edema; Retinal; Diabetic retinopathy; Diabetes mellitus; Internal medicine; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002373674,0.0003746259,0.0007117637,0.0004117784,0.0003701261,0.0003622613,0.0002526216,0.0007612573,0.000631609],"category_scores_gemma":[0.001123251,0.0001733037,0.0004359086,0.0003351076,0.0002381731,0.0004718018,0.0001380781,0.0007144827,0.00008516805],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004722278,"about_ca_system_score_gemma":0.0004122908,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002626368,"about_ca_topic_score_gemma":0.003519122,"domain_scores_codex":[0.9998428,0.00003679282,0.00001771069,0.00003055458,0.00003285,0.00003918921],"domain_scores_gemma":[0.9997374,0.0001070584,0.00004871215,0.000007702973,0.00001146769,0.00008756363],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.06566712,0.005498102,0.7206844,0.0004083425,0.0007478745,0.04873899,0.0005666129,0.001226056,0.02600449,0.0004159697,0.001851373,0.1281907],"study_design_scores_gemma":[0.004976214,0.02631883,0.9052237,0.00008591876,0.0009284254,0.0502589,0.0005571139,0.005777774,0.00361412,0.0004127953,0.001745539,0.000100637],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956473,0.002437501,0.0002295931,0.0002932443,0.00003528749,0.00002771967,0.00003934683,0.00002094211,0.001269197],"genre_scores_gemma":[0.9991583,0.0004119896,0.0001246937,0.0000988537,0.00003656304,0.000006599646,0.00003313831,0.000001202596,0.0001287226],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002626368,"threshold_uncertainty_score":0.005222142,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006670926387441641,"score_gpt":0.228402585689818,"score_spread":0.2217316593023763,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}