{"id":"W2965843521","doi":"10.1200/jco.2007.25.18_suppl.4086","title":"Encouraging results from a phase I study of capecitabine (X), irinotecan (I) and oxaliplatin (O) as first-line therapy in patients (pts) with metastatic colorectal cancer (MCRC)","year":2007,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Regional Cancer Foundation; Ottawa Hospital","funders":"","keywords":"Medicine; Neutropenia; Febrile neutropenia; Mucositis; Internal medicine; Capecitabine; Irinotecan; Anemia; Gastroenterology; Adverse effect; Toxicity; Oxaliplatin; Colorectal cancer; FOLFIRI; Diarrhea; Phases of clinical research; Surgery; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002141419,0.00101191,0.001349129,0.0002094737,0.0003367771,0.0006751045,0.0005130398,0.0006721994,0.001467594],"category_scores_gemma":[0.001350093,0.0003305905,0.000998655,0.0003519687,0.0006365063,0.0004412426,0.000204536,0.001931498,0.0002952365],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004443746,"about_ca_system_score_gemma":0.0009482902,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006127353,"about_ca_topic_score_gemma":0.001442609,"domain_scores_codex":[0.9995577,0.0002574968,0.00003314799,0.00005128981,0.00003840115,0.00006201127],"domain_scores_gemma":[0.9990839,0.000361158,0.0001264867,0.00007316161,0.0000465966,0.0003087021],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3738466,0.119399,0.02597154,0.002515736,0.00238697,0.001813348,0.001445621,0.007850675,0.2018806,0.000346106,0.009535442,0.2530085],"study_design_scores_gemma":[0.2041395,0.7282822,0.03892484,0.00005586041,0.0009923446,0.001460598,0.0000890866,0.001339297,0.01820665,0.0001409082,0.006321604,0.00004708461],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925971,0.002719159,0.00093981,0.000424735,0.00008052581,0.001020576,0.0005839072,0.00005043254,0.001583628],"genre_scores_gemma":[0.9871051,0.002963983,0.003067884,0.0009049744,0.0001992235,0.0009241577,0.002770482,0.00003447617,0.002029614],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002141419,"threshold_uncertainty_score":0.011325,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09401981366279662,"score_gpt":0.4577378627403398,"score_spread":0.3637180490775432,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}