{"id":"W2965861983","doi":"10.14336/ad.2019.0304","title":"Plasma Lipoprotein-associated Phospholipase A2 and Superoxide Dismutase are Independent Predicators of Cognitive Impairment in Cerebral Small Vessel Disease Patients: Diagnosis and Assessment","year":2019,"lang":"en","type":"article","venue":"Aging and Disease","topic":"Cerebrovascular and Carotid Artery Diseases","field":"Medicine","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Science and Technology Planning Project of Guangdong Province; National Natural Science Foundation of China","keywords":"Lipoprotein-associated phospholipase A2; Montreal Cognitive Assessment; Internal medicine; Superoxide dismutase; Cognition; Logistic regression; Lipoprotein; Phospholipase A2; Cognitive decline; Medicine; Cognitive impairment; Gastroenterology; Psychology; Disease; Dementia; Cholesterol; Psychiatry; Oxidative stress; Enzyme; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001600468,0.0002910124,0.0004406005,0.0001365589,0.00007826729,0.00005059915,0.0000540971,0.00005573085,0.00005448477],"category_scores_gemma":[0.0003305241,0.0002616348,0.0001227348,0.0001388892,0.0001483333,0.0001668114,0.0001552529,0.000178746,0.000002289886],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008064978,"about_ca_system_score_gemma":0.000221298,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00035657,"about_ca_topic_score_gemma":0.00004371729,"domain_scores_codex":[0.9982146,0.0001155725,0.0003453924,0.0005751488,0.0004091082,0.0003401649],"domain_scores_gemma":[0.998008,0.0001430894,0.0001387344,0.0002506557,0.00009141098,0.001368079],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00052631,0.002347964,0.9930274,0.0006916231,0.0001565456,0.0000662586,0.0003744603,0.00000356056,0.000004852768,0.00003049223,0.0000582724,0.002712184],"study_design_scores_gemma":[0.01031438,0.0002987566,0.9847153,0.001775941,0.000693445,0.0000020003,0.001269384,0.0004650902,0.00009321497,0.00008207816,0.00001570424,0.0002747311],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959895,0.001242688,0.000002674371,0.0003619747,0.00005712605,0.001445567,0.0008251372,0.00004066017,0.00003466381],"genre_scores_gemma":[0.998364,0.0004654119,0.00001145757,0.000402343,0.00002371907,0.0002578804,0.000416623,0.00003097775,0.00002762332],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009788069,"threshold_uncertainty_score":0.9999836,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006809441425978655,"score_gpt":0.2298580863959253,"score_spread":0.2230486449699467,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}