{"id":"W2965950376","doi":"10.3390/ijms20153843","title":"Olmesartan Attenuates Kidney Fibrosis in a Murine Model of Alport Syndrome by Suppressing Tubular Expression of TGFβ","year":2019,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Renin-Angiotensin System Studies","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Ministry of Science and ICT, South Korea; National Research Foundation of Korea; Chonnam National University; National Research Foundation","keywords":"Olmesartan; Downregulation and upregulation; Angiotensin II; Transforming growth factor; Kidney; Fibrosis; Endocrinology; Internal medicine; Cancer research; Renin–angiotensin system; Receptor; Medicine; Chemistry; Biochemistry; Blood pressure","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000156876,0.0006379401,0.000447321,0.0004999681,0.000180596,0.0002336731,0.0001987638,0.0003756619,0.00115005],"category_scores_gemma":[0.00008530671,0.0001383698,0.0002812049,0.0001374301,0.0003201264,0.0002938807,0.0001292582,0.001264768,0.0001980285],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001436223,"about_ca_system_score_gemma":0.0002717481,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002673497,"about_ca_topic_score_gemma":0.0005858486,"domain_scores_codex":[0.9998785,0.00002836654,0.00001339235,0.00001859752,0.00003618226,0.00002490898],"domain_scores_gemma":[0.9998436,0.0000107247,0.0000530318,0.000009238908,0.00001341321,0.00006987105],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001337712,0.0003261247,0.0003107597,0.0001324229,0.00002524494,0.0001604757,0.00002161377,0.0001086549,0.9933028,0.0001623513,0.00009459215,0.004017325],"study_design_scores_gemma":[0.0003514521,0.006304841,0.01135067,0.00003828573,0.000132869,0.0007486242,0.00009894263,0.002208574,0.97324,0.0003196494,0.005185638,0.00002039794],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877842,0.003322071,0.005468513,0.0004604811,0.0002084634,0.00006335941,0.0003509246,0.0003023437,0.002039716],"genre_scores_gemma":[0.9866301,0.00305851,0.004767737,0.0002026075,0.00009556599,0.0001032651,0.0003389542,0.00003648926,0.004766664],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00115005,"threshold_uncertainty_score":0.003847301,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01354477939478847,"score_gpt":0.2845338575105444,"score_spread":0.270989078115756,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}