{"id":"W2966033121","doi":"10.1016/j.celrep.2020.107625","title":"HNF4A and GATA6 Loss Reveals Therapeutically Actionable Subtypes in Pancreatic Cancer","year":2020,"lang":"en","type":"article","venue":"Cell Reports","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":127,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Roche Products; National Institutes of Health; Howat Foundation; Associazione Italiana per la Ricerca sul Cancro; Pancreatic Cancer Research Fund; Ministero della Salute; Cancer Australia; National Health and Medical Research Council; Cancer Research UK; American Association for Cancer Research; AstraZeneca; Celgene; Clovis Oncology; Ontario Institute for Cancer Research; Wellcome Trust; Roche; Merck KGaA","keywords":"GATA6; Pancreatic cancer; Cancer research; Medicine; Biology; Cancer; Bioinformatics; Genetics; Internal medicine; Transcription factor; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001189452,0.0001085889,0.0002177484,0.0003208829,0.000105386,0.0002696881,0.00009836384,0.0002110243,0.001198517],"category_scores_gemma":[0.0001452488,0.0001147164,0.0001522374,0.0001827604,0.0002032695,0.0001337966,0.0001743296,0.0003250483,0.0002082779],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001803295,"about_ca_system_score_gemma":0.0001050163,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005493357,"about_ca_topic_score_gemma":0.0008699661,"domain_scores_codex":[0.9999106,0.00001074967,0.000007174214,0.00002332953,0.00002337633,0.00002478405],"domain_scores_gemma":[0.9999324,0.00001096883,0.00001950648,0.000008988599,0.000005379195,0.00002272686],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007690146,0.00006677439,0.01507203,0.0000231531,0.00001802562,0.000091406,0.00003929494,0.0001774102,0.9760613,0.00009970413,0.00009071119,0.007491119],"study_design_scores_gemma":[0.00007208795,0.001795476,0.4903715,0.00001226685,0.00007273855,0.002372017,0.0003572919,0.002668232,0.4984215,0.0003672566,0.003474462,0.00001522352],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979585,0.0005200492,0.0005464808,0.00002972818,0.000004037616,0.0000105807,0.0002611313,0.00003636899,0.0006329869],"genre_scores_gemma":[0.9984443,0.0002345284,0.0002522249,0.0000343083,0.000002027626,0.00001466278,0.0003698288,0.000009467239,0.000638762],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001198517,"threshold_uncertainty_score":0,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04050781903931182,"score_gpt":0.3388110948411044,"score_spread":0.2983032758017926,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}