{"id":"W2966086076","doi":"10.3892/etm.2019.7845","title":"GSK343 induces autophagy and downregulates the AKT/mTOR signaling pathway in pancreatic cancer cells","year":2019,"lang":"en","type":"article","venue":"Experimental and Therapeutic Medicine","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Natural Science Foundation of China; Public Health Agency of Canada","keywords":"PI3K/AKT/mTOR pathway; Pancreatic cancer; Cell cycle; Protein kinase B; Autophagy; Viability assay; Cancer research; Apoptosis; Cell growth; Oncogene; Cancer; Biology; Cell; Cancer cell; Signal transduction; Chemistry; Cell biology; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002072504,0.0002359382,0.0004281427,0.00007943509,0.0000854371,0.00001517145,0.00009748773,0.00007983647,0.001495789],"category_scores_gemma":[0.000005233646,0.0001298501,0.00003946054,0.0001372351,0.0002735893,0.00005276606,0.00004953386,0.0001734767,0.00001372091],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004101214,"about_ca_system_score_gemma":0.00004738641,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002577952,"about_ca_topic_score_gemma":0.000002699627,"domain_scores_codex":[0.9988243,0.00007015755,0.0002760512,0.0003175847,0.00024803,0.0002638893],"domain_scores_gemma":[0.999378,0.0001358824,0.00007579959,0.0002518465,0.00001828354,0.000140209],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002641694,0.0001207374,0.004881638,0.00005673504,0.0001392355,0.00002484085,0.004840036,0.000001467734,0.9820937,0.0005216787,0.00002212484,0.007033661],"study_design_scores_gemma":[0.004952926,0.0008814699,0.03497653,0.0005049817,0.00008266882,0.0000468624,0.005656247,0.0003212929,0.9505477,0.000713118,0.001100149,0.0002160541],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9121394,0.08498725,0.000002055001,0.001359849,0.0002388201,0.0005765674,0.000002849268,0.00003115627,0.0006621346],"genre_scores_gemma":[0.9955347,0.000567544,0.00001893702,0.002812774,0.0002363392,0.00007604417,0.000005827428,0.00002530491,0.0007225284],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0844197,"threshold_uncertainty_score":0.999417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0193307269596461,"score_gpt":0.2933774836757055,"score_spread":0.2740467567160594,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}