{"id":"W2966086248","doi":"10.1021/acsbiomaterials.9b00425","title":"Induction of Fibrogenic Phenotype in Human Mesenchymal Stem Cells by Connective Tissue Growth Factor in a Hydrogel Model of Soft Connective Tissue","year":2019,"lang":"en","type":"article","venue":"ACS Biomaterials Science & Engineering","topic":"Connective Tissue Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Institute on Deafness and Other Communication Disorders; Global Institute for Water Security, University of Saskatchewan; National Institutes of Health; National Science Foundation","keywords":"CTGF; Connective tissue; Extracellular matrix; Cell biology; Mesenchymal stem cell; Growth factor; Fibrosis; Myofibroblast; Wound healing; Biology; Pathology; Chemistry; Immunology; Medicine; Biochemistry; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001842532,0.0003290692,0.0001590083,0.0002095923,0.0001066719,0.0001893408,0.0001084122,0.000253329,0.0006157676],"category_scores_gemma":[0.00005390128,0.00009139799,0.0002663638,0.0001506172,0.0001561651,0.0001409687,0.0001358874,0.0002652736,0.0001483242],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001762446,"about_ca_system_score_gemma":0.0001474242,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007897046,"about_ca_topic_score_gemma":0.001249446,"domain_scores_codex":[0.9999143,0.00001288883,0.00001053222,0.0000155023,0.00003121494,0.00001560327],"domain_scores_gemma":[0.999936,0.00001181652,0.00002081012,0.000007242889,0.000007485149,0.00001655237],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002896812,0.00001586233,0.00005404015,0.00003299431,0.00000214152,0.00005026918,0.00001504669,0.0001051866,0.9991636,0.00004208824,0.000009207837,0.000480628],"study_design_scores_gemma":[0.000006708516,0.0003132307,0.001066588,0.000006623091,0.000009429143,0.0001128188,0.00001713066,0.0008709818,0.9965969,0.00001825418,0.0009781083,0.00000338613],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990983,0.001505123,0.005729986,0.00005005531,0.00004084079,0.00007415397,0.0003329435,0.00005785028,0.001225952],"genre_scores_gemma":[0.9917946,0.001021854,0.005067978,0.00003329308,0.00001275987,0.00005834848,0.0002738328,0.00000961762,0.001727732],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007897046,"threshold_uncertainty_score":0.002059996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01450441538566194,"score_gpt":0.2655645284882073,"score_spread":0.2510601131025453,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}