{"id":"W2966095624","doi":"10.3389/fonc.2019.00753","title":"The Flick of a Switch: Conferring Survival Advantage to Breast Cancer Stem Cells Through Metabolic Plasticity","year":2019,"lang":"en","type":"review","venue":"Frontiers in Oncology","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research","keywords":"Epigenetics; Carcinogenesis; Cancer research; Biology; Cancer stem cell; Breast cancer; Epithelial–mesenchymal transition; Stem cell; Anaerobic glycolysis; Transcription factor; Chromatin; Cancer cell; Metastasis; Tumor microenvironment; Cell biology; Cancer; Biochemistry; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004121839,0.0005070389,0.002453669,0.0001284227,0.00007632942,0.00001972267,0.0008112082,0.0007089128,0.00001717079],"category_scores_gemma":[0.00003552709,0.00038113,0.0004833624,0.0002815677,0.0002360673,0.000006502342,0.0003869466,0.0004442048,0.0000128658],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001653263,"about_ca_system_score_gemma":0.001485257,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002289731,"about_ca_topic_score_gemma":0.000643184,"domain_scores_codex":[0.9971246,0.0004346009,0.0008351353,0.0007366082,0.0002133265,0.0006557953],"domain_scores_gemma":[0.9984795,0.0001093741,0.0005477419,0.0006162794,0.0001215445,0.0001255527],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002486184,0.00009274251,0.0001058232,0.001727745,0.0006114783,0.000003506103,0.0001384439,0.00005404996,0.0007698304,0.0002097491,0.01782574,0.9782123],"study_design_scores_gemma":[0.0006676845,0.000120343,0.00004093225,0.0005255647,0.0005822774,0.00002323532,0.0002294679,0.000004245176,0.0004598252,0.00001102117,0.9969473,0.0003881052],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002531165,0.9782937,0.00166556,0.00005732242,0.01700075,0.001155054,0.0006713839,0.000009137097,0.0008940432],"genre_scores_gemma":[0.00009053557,0.9954759,0.0006465156,0.0001352124,0.001771542,0.0002906468,0.00003908121,0.00007923934,0.001471328],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9791216,"threshold_uncertainty_score":0.999864,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03580944904050777,"score_gpt":0.3412852217239682,"score_spread":0.3054757726834605,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}