{"id":"W2966101753","doi":"10.1021/acs.joc.9b01305","title":"Inhibitory Evaluation of αPMM/PGM from <i>Pseudomonas aeruginosa</i>: Chemical Synthesis, Enzyme Kinetics, and Protein Crystallographic Study","year":2019,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Glycomics Network; Canadian Institutes of Health Research; National Science Foundation","keywords":"Chemistry; Pseudomonas aeruginosa; Kinetics; Enzyme; Enzyme kinetics; Pseudomonadales; Stereochemistry; Pseudomonadaceae; Biochemistry; Bacteria; Active site","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001447801,0.0002970562,0.0002162321,0.0001089194,0.000122879,0.0001262077,0.000287301,0.0001687461,0.0005253982],"category_scores_gemma":[0.0001481313,0.00008194191,0.0001518706,0.0002165837,0.0001027964,0.0001227393,0.00008611751,0.0003172486,0.0001919976],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003757,"about_ca_system_score_gemma":0.000281872,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002748879,"about_ca_topic_score_gemma":0.002584711,"domain_scores_codex":[0.9999052,0.00001866002,0.000009595084,0.00001618929,0.00003092237,0.00001945546],"domain_scores_gemma":[0.9999393,0.000009888649,0.0000188785,0.000005446421,0.00001503493,0.0000115033],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001685441,0.00009132845,0.0001051233,0.000107796,0.000006171303,0.00004731623,0.00001715263,0.0005873978,0.9960722,0.00007486204,0.00009697529,0.002625284],"study_design_scores_gemma":[0.000013669,0.000390337,0.0004520537,0.000004072243,0.000008211797,0.00004249554,0.000006749733,0.0007673327,0.9968286,0.000008266705,0.001474163,0.000004067042],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891654,0.003923096,0.002945964,0.0001081007,0.00002583691,0.00009119223,0.0008133803,0.00008098948,0.002846031],"genre_scores_gemma":[0.9870887,0.004229126,0.005852669,0.00004133866,0.00001361118,0.00006312975,0.0008930338,0.00002607788,0.001792264],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002748879,"threshold_uncertainty_score":0.005465806,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008165245175857141,"score_gpt":0.2172252118942282,"score_spread":0.2090599667183711,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}