{"id":"W2966101753","doi":"10.1021/acs.joc.9b01305","title":"Inhibitory Evaluation of αPMM/PGM from <i>Pseudomonas aeruginosa</i>: Chemical Synthesis, Enzyme Kinetics, and Protein Crystallographic Study","year":2019,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Glycomics Network; Canadian Institutes of Health Research; National Science Foundation","keywords":"Chemistry; Pseudomonas aeruginosa; Kinetics; Enzyme; Enzyme kinetics; Pseudomonadales; Stereochemistry; Pseudomonadaceae; Biochemistry; Bacteria; Active site","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009636251,0.0001527037,0.0002207065,0.00002533765,0.00003029161,0.00001359172,0.0001970996,0.0001483301,0.0004882299],"category_scores_gemma":[0.0002851448,0.000116818,0.00008524199,0.00009334445,0.00009986476,0.000009232661,0.00009202282,0.0002143218,0.000002026643],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002836792,"about_ca_system_score_gemma":0.0001160973,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005950971,"about_ca_topic_score_gemma":0.000003226738,"domain_scores_codex":[0.9986283,0.0001555327,0.0004449294,0.0001738631,0.0004752337,0.0001220958],"domain_scores_gemma":[0.9987726,0.00004589216,0.0004244411,0.0003241984,0.0003640464,0.00006881962],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001915046,0.0002467311,0.001357521,0.0000261577,0.0001054051,7.481433e-7,0.00009901247,0.00000917843,0.9973661,3.551902e-7,0.0004183816,0.0001788864],"study_design_scores_gemma":[0.001343891,0.0002466144,0.001038102,0.00008780444,0.0002197981,0.0000509693,0.0007904834,0.00001402763,0.9957876,0.00004760157,0.0002496321,0.000123432],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975477,0.001570506,0.00004853566,0.0001089347,0.00008448541,0.0002626187,0.000007672118,0.000004349637,0.0003651323],"genre_scores_gemma":[0.9993603,0.00009719772,0.00006425894,0.00003592011,0.0003172221,0.000004928143,0.00001112601,0.00001957621,0.00008953399],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001812471,"threshold_uncertainty_score":0.5345775,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008165245175857141,"score_gpt":0.2172252118942282,"score_spread":0.2090599667183711,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}