{"id":"W2966111642","doi":"10.3390/cells8080804","title":"Cholesterol Interaction Directly Enhances Intrinsic Activity of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)","year":2019,"lang":"en","type":"article","venue":"Cells","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research; Cystic Fibrosis Canada","keywords":"Cystic fibrosis transmembrane conductance regulator; Gating; Ivacaftor; Phosphorylation; Chemistry; Cystic fibrosis; Cell biology; Biophysics; Biochemistry; Transmembrane protein; Cholesterol; Long-term potentiation; Biology; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001780832,0.0001678276,0.0003970977,0.00007645178,0.00004678228,0.00002116646,0.0002048989,0.00007336159,0.0004104475],"category_scores_gemma":[0.0001367316,0.0001146829,0.0001502512,0.0003257942,0.0001930318,0.0002584496,0.00004891121,0.0003000682,0.0001271827],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001005328,"about_ca_system_score_gemma":0.00009860975,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005045204,"about_ca_topic_score_gemma":0.00002354098,"domain_scores_codex":[0.9985498,0.0001117992,0.0002640727,0.0003318141,0.000465484,0.0002770521],"domain_scores_gemma":[0.998651,0.0003701131,0.0001688649,0.0005885747,0.0001203416,0.0001010946],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005340549,0.0001140525,0.0007406549,0.0005825236,0.00003819173,9.542464e-7,0.0001657383,0.00003287625,0.9877863,0.0000100953,0.0001744118,0.009820157],"study_design_scores_gemma":[0.0009112222,0.0002884571,0.03986338,0.0005705493,0.00004290127,0.00001352617,0.0000605363,0.0002152357,0.9538897,0.00002334746,0.004017677,0.0001034931],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962344,0.0002444033,0.0001484719,0.0003738916,0.0006974582,0.0007933422,0.00002392431,0.00003702697,0.001447084],"genre_scores_gemma":[0.9966836,0.00006125926,0.0006484762,0.00005943088,0.00008645272,0.00002166308,0.000003749571,0.0000232271,0.002412115],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03912272,"threshold_uncertainty_score":0.4676632,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01156293744569898,"score_gpt":0.2762578583272584,"score_spread":0.2646949208815594,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}