{"id":"W2966163101","doi":"10.1128/aem.01292-19","title":"The ADEP Biosynthetic Gene Cluster in Streptomyces hawaiiensis NRRL 15010 Reveals an Accessory <i>clpP</i> Gene as a Novel Antibiotic Resistance Factor","year":2019,"lang":"en","type":"article","venue":"Applied and Environmental Microbiology","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Deutsche Forschungsgemeinschaft; Government of Canada; Canadian Institutes of Health Research; Deutsches Zentrum für Infektionsforschung","keywords":"Gene cluster; Streptomyces; Biology; Gene; Antibiotic resistance; Bacteria; Microbiology; Protease; Antibiotics; Antimicrobial; Genetics; Computational biology; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006249606,0.0003707492,0.0002040544,0.0002538575,0.0001009838,0.0002517742,0.0001569915,0.0001552581,0.0007539543],"category_scores_gemma":[0.0001509655,0.0001120505,0.0002846029,0.0003072754,0.0001452279,0.0001223371,0.0002583547,0.0002956869,0.0003910523],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002632062,"about_ca_system_score_gemma":0.0003286726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00368855,"about_ca_topic_score_gemma":0.002766821,"domain_scores_codex":[0.9999071,0.000009247305,0.00001178396,0.00003026496,0.00002631751,0.00001517888],"domain_scores_gemma":[0.9999002,0.00001556451,0.00002649749,0.00001262253,0.00001424225,0.0000309715],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006020543,0.00002228697,0.001445019,0.00003890863,0.000004746836,0.0001391328,0.000029909,0.00006458705,0.994958,0.00004191064,0.00002736679,0.003167938],"study_design_scores_gemma":[0.0000281573,0.0004755996,0.1113077,0.00002934454,0.00008177741,0.002931933,0.0004751177,0.003454859,0.8715479,0.0001899332,0.009444204,0.00003361359],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934446,0.0004109905,0.003632084,0.00006434425,0.00001414701,0.00003597008,0.00127759,0.000101751,0.001018564],"genre_scores_gemma":[0.9819333,0.0003267194,0.008833564,0.00005959748,0.000007179096,0.00004217088,0.006073818,0.00004662841,0.002677024],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00368855,"threshold_uncertainty_score":0.007334173,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006439763504845657,"score_gpt":0.20454028299797,"score_spread":0.1981005194931243,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}