{"id":"W2966185030","doi":"10.1021/jacs.9b05499","title":"The Role of Protein Thermodynamics and Primary Structure in Fibrillogenesis of Variable Domains from Immunoglobulin Light Chains","year":2019,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Amyloidosis: Diagnosis, Treatment, Outcomes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Canadian Institutes of Health Research; National Institutes of Health; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Chemistry; Immunoglobulin light chain; Protein aggregation; Fibrillogenesis; Immunoglobulin domain; Protein folding; Biophysics; Amyloid (mycology); Fibril; Crystallography; Antibody; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007421482,0.0001909433,0.0002391502,0.0003017494,0.0002768167,0.0003523892,0.0002159233,0.0002215325,0.0005375525],"category_scores_gemma":[0.001549572,0.0001759719,0.0001683546,0.0001491877,0.0004290289,0.0004040932,0.0002241262,0.0003144949,0.0001107606],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003042522,"about_ca_system_score_gemma":0.0003299501,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001061718,"about_ca_topic_score_gemma":0.001073487,"domain_scores_codex":[0.999785,0.00007265395,0.00001066701,0.00003564645,0.00005615585,0.00003979665],"domain_scores_gemma":[0.9993667,0.0002579858,0.0001998642,0.00003642034,0.00007105803,0.00006795629],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006968073,0.000131704,0.03899895,0.0001088467,0.00006855791,0.0003044356,0.0002360965,0.00333905,0.9432265,0.001152224,0.00005925899,0.01167761],"study_design_scores_gemma":[0.00004025037,0.0008739691,0.367596,0.0000364951,0.0001261004,0.001203346,0.000216719,0.02594655,0.5985171,0.004661355,0.0007182164,0.00006393768],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995797,0.0009182437,0.002611117,0.00007946449,0.000008573109,0.00001122328,0.00004292167,0.00001786745,0.0005135244],"genre_scores_gemma":[0.999398,0.0001477206,0.0003460054,0.000009575593,0.000004678929,0.000003383883,0.00001992965,0.000005224194,0.00006536465],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001061718,"threshold_uncertainty_score":0.003924906,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.001700012027021908,"score_gpt":0.194112664807934,"score_spread":0.192412652780912,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}