{"id":"W2966222235","doi":"10.1787/fde13d2c-en","title":"Adverse Outcome Pathway on Aryl hydrogen receptor activation leading to uroporphyria","year":2019,"lang":"en","type":"paratext","venue":"OECD series on adverse outcome pathways","topic":"Porphyrin Metabolism and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Environment and Climate Change Canada","funders":"","keywords":"Uroporphyrinogen III decarboxylase; Aryl hydrocarbon receptor; Heme; Chemistry; Cytochrome P450; Enzyme; Porphyria; Aryl; Ligand (biochemistry); Stereochemistry; Biochemistry; Receptor; Transcription factor; Biology; Endocrinology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["metaepi_narrow","insufficient_payload"],"category_scores_codex":[0.0004619263,0.001458685,0.001435787,0.0005125259,0.0003357816,0.00006628114,0.001035542,0.001218666,0.002951348],"category_scores_gemma":[0.0003362145,0.001418692,0.0008923017,0.0002813624,0.0001515483,0.00005005191,0.0004635284,0.0008358721,0.07203989],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002111034,"about_ca_system_score_gemma":0.0003661462,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003543237,"about_ca_topic_score_gemma":0.00001972272,"domain_scores_codex":[0.9945235,0.0002055054,0.00124172,0.00197768,0.0008564832,0.00119514],"domain_scores_gemma":[0.9962959,0.00006720736,0.0008003387,0.002135827,0.0001634873,0.0005372092],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.004093023,0.0007968014,0.003650443,0.0006923864,0.0006696236,0.00004082398,0.0004535932,0.008833113,0.6490219,0.002193392,0.3267492,0.002805706],"study_design_scores_gemma":[0.001536239,0.001034314,0.0004462173,0.0001134358,0.00005528892,0.000004785011,0.0003825676,0.000003365901,0.1630283,0.00001799877,0.8318391,0.001538336],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6992208,0.0002998449,0.0004228816,0.0007139415,0.01260833,0.003207338,0.003928315,0.0002122025,0.2793864],"genre_scores_gemma":[0.5010325,0.0006168628,0.000878947,0.009989578,0.002389922,0.000416442,0.0115863,0.0006566903,0.4724328],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5050899,"threshold_uncertainty_score":0.9998163,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02460621033889052,"score_gpt":0.2732550530656873,"score_spread":0.2486488427267967,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}