{"id":"W2966250420","doi":"10.1128/jvi.00854-19","title":"Kaposi’s Sarcoma-Associated Herpesvirus Lytic Replication Interferes with mTORC1 Regulation of Autophagy and Viral Protein Synthesis","year":2019,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Viral-associated cancers and disorders","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Beatrice Hunter Cancer Research Institute; Dalhousie University","funders":"Canadian Institutes of Health Research; Government of Canada","keywords":"Lytic cycle; Biology; mTORC1; Kaposi's sarcoma-associated herpesvirus; Cell biology; Autophagy; Viral replication; Autophagy-related protein 13; Virology; Virus; Kinase; Protein kinase A; Signal transduction; Genetics; Protein phosphorylation; Herpesviridae; PI3K/AKT/mTOR pathway","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[{"model":"gemma","categories":[],"domain":null,"study_design":"bench_or_experimental","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"low","status":"direct model label, unvalidated"},{"model":"gpt","categories":[],"domain":null,"study_design":"bench_or_experimental","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"high","status":"direct model label, unvalidated"}],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002350307,0.0003166041,0.0003888039,0.0002699271,0.0001936737,0.0004186153,0.0002685038,0.0002851458,0.0009871578],"category_scores_gemma":[0.0002362703,0.0001636821,0.0002568565,0.000177494,0.0003340291,0.0002660476,0.0002635666,0.0006578721,0.000221275],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003751685,"about_ca_system_score_gemma":0.0003219312,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004826008,"about_ca_topic_score_gemma":0.0008577806,"domain_scores_codex":[0.9996591,0.00007836227,0.00004603663,0.00004716482,0.00007831214,0.00009117113],"domain_scores_gemma":[0.9998331,0.00004846528,0.00003521599,0.00003161338,0.00001425771,0.00003733228],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002753094,0.00007990936,0.0001628178,0.00005270989,0.000008143405,0.00003950267,0.00001497694,0.00009942881,0.9965809,0.0003858702,0.0001003505,0.00220006],"study_design_scores_gemma":[0.00002642053,0.0003863095,0.002276117,0.000006798678,0.00001542674,0.000181637,0.00001944415,0.001559511,0.9926433,0.00009587668,0.002782255,0.000007067194],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903424,0.003947451,0.00192291,0.0001792544,0.0001136668,0.00003513196,0.0003549709,0.0001241362,0.002979975],"genre_scores_gemma":[0.9964519,0.0006953827,0.001089286,0.00004099691,0.00001834613,0.00003003646,0.000276158,0.00001665273,0.001381394],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009871578,"threshold_uncertainty_score":0.003302395,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008435395781704047,"score_gpt":0.2471599289319409,"score_spread":0.2387245331502368,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}