{"id":"W2966328271","doi":"10.1186/s12870-019-1889-5","title":"Outlook for coeliac disease patients: towards bread wheat with hypoimmunogenic gluten by gene editing of α- and γ-gliadin gene families","year":2019,"lang":"en","type":"article","venue":"BMC Plant Biology","topic":"Celiac Disease Research and Management","field":"Medicine","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"FP7 People: Marie-Curie Actions; Institute of Genetics; Biotechnology and Biological Sciences Research Council; Institute of Genetics and Developmental Biology, Chinese Academy of Sciences; Chinese Academy of Sciences","keywords":"Biology; Gliadin; Epitope; Gluten; Gene; Genetics; CRISPR; Immunogenicity; Endosperm; Cas9; Population; Antibody; Food science","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001511087,0.0001710554,0.0003766362,0.0001081654,0.00004208815,0.000008982461,0.00009309956,0.00006315771,0.00003503805],"category_scores_gemma":[0.00009539023,0.0001210172,0.00007861359,0.00006398029,0.0001226598,0.00004339198,0.0001064676,0.00006380065,0.000009107843],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004122577,"about_ca_system_score_gemma":0.0001383746,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001821068,"about_ca_topic_score_gemma":0.00002678734,"domain_scores_codex":[0.9988131,0.00004389718,0.000238643,0.000346854,0.0001664001,0.0003910934],"domain_scores_gemma":[0.9991979,0.00009218845,0.00008682902,0.0002631194,0.0001193341,0.0002406552],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.009729843,0.0006475659,0.8883299,0.001573308,0.0005897762,0.00001906095,0.00009084583,0.000005529979,0.06466297,0.0002352117,0.01768536,0.0164306],"study_design_scores_gemma":[0.04198341,0.01098584,0.7707487,0.0007627418,0.001523162,0.00006387363,0.0008554059,0.002398037,0.04148319,0.0002701273,0.1276468,0.001278652],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99031,0.003527506,0.0003971093,0.0001913676,0.0001200448,0.001387171,0.003802862,0.00002885985,0.0002350675],"genre_scores_gemma":[0.9891148,0.001596969,0.001181734,0.0003138458,0.0001383463,0.0001623816,0.006562522,0.00002828589,0.0009011836],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1175812,"threshold_uncertainty_score":0.4934939,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01318328670821221,"score_gpt":0.2530328945945535,"score_spread":0.2398496078863413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}