{"id":"W2966328271","doi":"10.1186/s12870-019-1889-5","title":"Outlook for coeliac disease patients: towards bread wheat with hypoimmunogenic gluten by gene editing of α- and γ-gliadin gene families","year":2019,"lang":"en","type":"article","venue":"BMC Plant Biology","topic":"Celiac Disease Research and Management","field":"Medicine","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"FP7 People: Marie-Curie Actions; Institute of Genetics; Biotechnology and Biological Sciences Research Council; Institute of Genetics and Developmental Biology, Chinese Academy of Sciences; Chinese Academy of Sciences","keywords":"Biology; Gliadin; Epitope; Gluten; Gene; Genetics; CRISPR; Immunogenicity; Endosperm; Cas9; Population; Antibody; Food science","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001964393,0.0003518129,0.0002851172,0.0001006547,0.0001873689,0.000467418,0.0001794734,0.0004955227,0.002251351],"category_scores_gemma":[0.000163728,0.00005706322,0.0003132271,0.0001015677,0.0001464176,0.0002651638,0.0002445807,0.0005509455,0.0006755631],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001945011,"about_ca_system_score_gemma":0.0001538643,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003203765,"about_ca_topic_score_gemma":0.0003729917,"domain_scores_codex":[0.9999342,0.00001444105,0.000005353161,0.00001781505,0.00001097509,0.00001725287],"domain_scores_gemma":[0.9999145,0.00001018531,0.00001606864,0.000005451524,0.00001352005,0.00004032136],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002976438,0.0007806232,0.03437288,0.001210194,0.0001690793,0.005329663,0.0004096052,0.000596927,0.6500394,0.001754656,0.01538658,0.2869739],"study_design_scores_gemma":[0.002508974,0.0179921,0.1747744,0.001453346,0.001888264,0.07526656,0.002652197,0.005491155,0.2778039,0.009765029,0.430244,0.0001601706],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8822131,0.05590167,0.02798709,0.02030926,0.000832896,0.0001684275,0.001082218,0.0009200667,0.01058522],"genre_scores_gemma":[0.9035208,0.03925974,0.0334665,0.009971867,0.000564168,0.0001768697,0.002655951,0.00016159,0.01022244],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002251351,"threshold_uncertainty_score":0.007531524,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01318328670821221,"score_gpt":0.2530328945945535,"score_spread":0.2398496078863413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}