{"id":"W2966369225","doi":"10.21037/sci.2019.06.01","title":"SETD7 at the heart of chromatin factor interplay","year":2019,"lang":"en","type":"letter","venue":"Stem Cell Investigation","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Ontario Ministry of Research, Innovation and Science; Fundação de Amparo à Pesquisa do Estado de São Paulo; Novartis Pharma; Wellcome Trust; Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Genome Canada; Ontario Genomics; Pfizer","keywords":"Epigenetics; Biology; Chromatin; Histone; DNA methylation; Epigenomics; Transcription factor; Genetics; Epigenetic regulation of neurogenesis; Computational biology; Gene expression; Cell biology; Gene; Chromatin remodeling","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005669711,0.0004492259,0.000387403,0.0002089638,0.0008481975,0.001158657,0.0005849057,0.005488733,0.00554157],"category_scores_gemma":[0.001887287,0.0002300301,0.000296423,0.0001314342,0.001168693,0.0007337249,0.0006939797,0.006587618,0.00453013],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001272785,"about_ca_system_score_gemma":0.0004024463,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004627628,"about_ca_topic_score_gemma":0.00105075,"domain_scores_codex":[0.9995184,0.0001046408,0.00004113673,0.0000959672,0.0001577353,0.00008212831],"domain_scores_gemma":[0.9993336,0.0002894926,0.0000586793,0.00005548581,0.0001175122,0.0001452032],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007335295,0.00006602439,0.004303219,0.0003938105,0.0000824688,0.01927369,0.0002532444,0.0003273025,0.03114205,0.02788723,0.8190691,0.09646825],"study_design_scores_gemma":[0.000166646,0.000182566,0.003210005,0.0002713111,0.00005160538,0.01593946,0.0002643021,0.001093807,0.01559027,0.02153055,0.94165,0.00004939681],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"editorial","genre_scores_codex":[0.01522235,0.03218324,0.003242694,0.8449025,0.06853266,0.00006462639,0.0002892979,0.0002500285,0.03531272],"genre_scores_gemma":[0.2299277,0.02610159,0.001908807,0.5468184,0.1239813,0.0001884578,0.0002637027,0.0001067973,0.07070324],"genre_candidate":"editorial","genre_consensus":null,"teacher_disagreement_score":0.00554157,"threshold_uncertainty_score":0.01853836,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01963556787383579,"score_gpt":0.2667777401181267,"score_spread":0.2471421722442909,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}