{"id":"W2966411388","doi":"10.1182/blood.2018890764","title":"Inherited genetic susceptibility to acute lymphoblastic leukemia in Down syndrome","year":2019,"lang":"en","type":"review","venue":"Blood","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine","funders":"National Center for Chronic Disease Prevention and Health Promotion; National Institute of General Medical Sciences; University of California, San Diego; University of California, Davis; Centers for Disease Control and Prevention; National Institutes of Health; National Institute of Environmental Health Sciences; University of California, Los Angeles; American Lebanese Syrian Associated Charities; University of Washington; California Department of Public Health; Pediatric Cancer Research Foundation; Washington State University; Pride Foundation; Children's Hospital Los Angeles; National Cancer Institute; Kaiser Permanente; Cancer Prevention and Research Institute of Texas; University of Southern California; Cedars-Sinai Medical Center; Alex's Lemonade Stand Foundation for Childhood Cancer; University of California, San Francisco; Children's Hospital of Philadelphia","keywords":"Allele; Penetrance; Biology; CDKN2A; Genetics; Genome-wide association study; Locus (genetics); Immunology; Single-nucleotide polymorphism; Gene; Genotype; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005457611,0.001052685,0.00443124,0.001202795,0.00005673078,0.00007642585,0.0009065609,0.001113512,0.0005079891],"category_scores_gemma":[0.0007320958,0.0008642821,0.0007517593,0.002320984,0.0001619972,0.0000752906,0.000711922,0.001139963,0.005351877],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.007792383,"about_ca_system_score_gemma":0.01148718,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003587281,"about_ca_topic_score_gemma":0.00006753035,"domain_scores_codex":[0.9936899,0.0003707883,0.001628513,0.001733488,0.001161306,0.001416025],"domain_scores_gemma":[0.9957476,0.0006820525,0.000291802,0.002268165,0.0001930599,0.0008173598],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006280787,0.002975549,0.00185485,0.1905708,0.00630069,0.03787897,0.0004324427,0.00004150912,0.000204614,0.00003077792,0.005485716,0.7535959],"study_design_scores_gemma":[0.02013545,0.003720655,0.00774451,0.07391465,0.01774403,0.03077656,0.00003647204,0.0002295011,0.00002119295,0.00002942276,0.8428939,0.002753672],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.03325905,0.9589703,0.00005819606,0.00003671572,0.0003560696,0.005943167,0.0002229427,0.0001865667,0.0009669602],"genre_scores_gemma":[0.001526096,0.992434,0.00160247,0.0002115311,0.0002621824,0.0005688774,0.0003087045,0.0003029058,0.002783182],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8374082,"threshold_uncertainty_score":0.9993808,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03444359123348251,"score_gpt":0.3287497320057195,"score_spread":0.294306140772237,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}