{"id":"W2966411388","doi":"10.1182/blood.2018890764","title":"Inherited genetic susceptibility to acute lymphoblastic leukemia in Down syndrome","year":2019,"lang":"en","type":"review","venue":"Blood","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine","funders":"National Center for Chronic Disease Prevention and Health Promotion; National Institute of General Medical Sciences; University of California, San Diego; University of California, Davis; Centers for Disease Control and Prevention; National Institutes of Health; National Institute of Environmental Health Sciences; University of California, Los Angeles; American Lebanese Syrian Associated Charities; University of Washington; California Department of Public Health; Pediatric Cancer Research Foundation; Washington State University; Pride Foundation; Children's Hospital Los Angeles; National Cancer Institute; Kaiser Permanente; Cancer Prevention and Research Institute of Texas; University of Southern California; Cedars-Sinai Medical Center; Alex's Lemonade Stand Foundation for Childhood Cancer; University of California, San Francisco; Children's Hospital of Philadelphia","keywords":"Allele; Penetrance; Biology; CDKN2A; Genetics; Genome-wide association study; Locus (genetics); Immunology; Single-nucleotide polymorphism; Gene; Genotype; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001182463,0.0009226201,0.0007629698,0.001138639,0.0003271377,0.0008076802,0.0005114063,0.000494644,0.002385647],"category_scores_gemma":[0.00307339,0.0004538651,0.001576784,0.001395033,0.0003679091,0.0002798954,0.00060871,0.000583206,0.0001391894],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002898053,"about_ca_system_score_gemma":0.0002297622,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004264365,"about_ca_topic_score_gemma":0.003466903,"domain_scores_codex":[0.9987979,0.000440005,0.0001498544,0.0003712366,0.0001668885,0.00007404765],"domain_scores_gemma":[0.9989453,0.0005026513,0.0002985583,0.0001218408,0.00005905642,0.00007266731],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001096226,0.00002265441,0.9720846,0.0002984137,0.005924946,0.00161675,0.0001016124,0.0003612135,0.006698864,0.0002802992,0.0003290794,0.01118533],"study_design_scores_gemma":[0.0002322079,0.0001861382,0.9829556,0.0001237801,0.00655193,0.004867486,0.0000870225,0.001107634,0.001286487,0.0006112988,0.001969517,0.00002087877],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9864564,0.009400805,0.001854439,0.0001562116,0.00005718019,0.00001683803,0.001167053,0.00004600942,0.0008451926],"genre_scores_gemma":[0.9963831,0.001919404,0.0008207462,0.00006192732,0.00004150596,0.00001408763,0.000557246,0.000009267468,0.0001927562],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.004264365,"threshold_uncertainty_score":0.008479059,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03444359123348251,"score_gpt":0.3287497320057195,"score_spread":0.294306140772237,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}