{"id":"W2966490059","doi":"10.1186/s40249-019-0573-1","title":"The urgent need for more potent antiretroviral therapy in low-income countries to achieve UNAIDS 90-90-90 and complete eradication of AIDS by 2030","year":2019,"lang":"en","type":"letter","venue":"Infectious Diseases of Poverty","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Institute of Allergy and Infectious Diseases; Academisch Medisch Centrum; Universiteit van Amsterdam","keywords":"Efavirenz; Nevirapine; Medicine; Developing country; Public health; Tolerability; Regimen; Drug resistance; Lamivudine; Environmental health; Adverse effect; Human immunodeficiency virus (HIV); Viral load; Virology; Antiretroviral therapy; Pharmacology; Economic growth; Internal medicine; Hepatitis B virus; Biology; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001866028,0.0004884643,0.001028539,0.0003507623,0.0001308424,0.00004378846,0.0001943383,0.0002826636,0.00003888293],"category_scores_gemma":[0.0001536438,0.0003278302,0.0003229303,0.0002744953,0.00022928,0.0000972458,0.00007516073,0.0003207379,0.0000107255],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003480684,"about_ca_system_score_gemma":0.0003724995,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003184392,"about_ca_topic_score_gemma":0.00002143474,"domain_scores_codex":[0.9975986,0.0001034102,0.0007208921,0.0004908381,0.0006319122,0.0004543164],"domain_scores_gemma":[0.9981083,0.0005065086,0.0004175078,0.0005574094,0.0002482771,0.0001619675],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001540052,0.0005011816,0.5497517,0.001089545,0.001141814,0.00002435134,0.0003153028,0.00001178416,0.000160283,0.00005350944,0.4417778,0.003632673],"study_design_scores_gemma":[0.02262119,0.009246289,0.3407435,0.002512484,0.001743224,0.00003905588,0.0002157364,0.000338369,0.001122895,0.0005645729,0.6192915,0.001561211],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7469818,0.006604164,0.0002185987,0.2348197,0.000817443,0.006261421,0.00399171,0.0001053292,0.0001998303],"genre_scores_gemma":[0.9008821,0.002142142,0.0001105659,0.09020789,0.0004675222,0.0004762271,0.002233158,0.0001266067,0.003353834],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2090083,"threshold_uncertainty_score":0.9999174,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007090802984421769,"score_gpt":0.2496463733184352,"score_spread":0.2425555703340134,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}